Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri Lanka

被引：19

作者：

Centko, Ryan M. ^{[1
]}

Ratnaweera, Pamoda B. ^{[2
]}

Tysoe, Christina ^{[3
]}

Withers, Stephen G. ^{[3
]}

de Silva, E. Dilip ^{[4
]}

Andersen, Raymond J. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem & Earth Ocean & Atmospher Sci, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada

[2] Uva Wellassa Univ, Dept Sci & Technol, Passara Rd, Badulla, Sri Lanka

[3] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada

[4] Univ Colombo, Dept Chem, Colombo 03, Sri Lanka

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 22卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Thiodiketopiperazines; Setosphaeria rostrata; Endophytic fungi; Costus speciosus; alpha-Glucosidase inhibitory activity; Porcine pancreatic alpha amylase inhibitory activity;

D O I：

10.1016/j.phytol.2017.09.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new thiodiketopiperazine derivatives, rostratazine A (1), rostratazine B (2) and rostratazine C (3) along with exserohilone (4) and boydine A (5) were isolated and identified from the laboratory culture of Setosphaeria rostrata, an endophytic fungus obtained from the fresh asymptomatic leaf tissues of the medicinal plant Costus speciosus from Sri Lanka. The structures of compounds 1-3 were elucidated on the basis of detailed interpretation of 1D-and 2D-NMR data and comparison to known compounds. Compounds 1-5 were subjected to a-glucosidase inhibitory and porcine pancreatic alpha amylase inhibitory assays and 4 showed alpha-glucosidase inhibitory activity while 2 showed porcine pancreatic alpha amylase inhibitory activity.

引用

页码：76 / 80

页数：5

共 16 条

[1] Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds [J].

Alvin, Alfonsus ;

Miller, Kristin I. ;

Neilan, Brett A. .

MICROBIOLOGICAL RESEARCH, 2014, 169 (7-8) :483-495

[2]

Dissanayake R. K., 2016, Journal of Applied Pharmaceutical Science, V6, P1

[3]

Fouda A. H., 2015, Annals of Agricultural Science (Cairo), V60, P95

[4] Diketopiperazines from the Cordyceps-Colonizing Fungus Epicoccum nigrum [J].

Guo, Huijuan ;

Sun, Bingda ;

Gao, Hao ;

Chen, Xulin ;

Liu, Shuchun ;

Yao, Xinsheng ;

Liu, Xingzhong ;

Che, Yongsheng .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (12) :2115-2119

[5]

Kariyawasam GK, 2012, 5 ANN SESS I BIOCH M, V5, P49

[6]

Pawar V.A., 2014, Int. J. Sci. Res., V3, P28

[7] Effects of flavonoids on α-glucosidase activity: Potential targets for glucose homeostasis [J].

Pereira, Danielle Fontana ;

Cazarolli, Luisa Helena ;

Lavado, Cristiane ;

Mengatto, Vanessa ;

Reis Bonorino Figueiredo, Maria Santos ;

Guedes, Alessandro ;

Pizzolatti, Moacir Geraldo ;

Mena Barreto Silva, Fatima Regina .

NUTRITION, 2011, 27 (11-12) :1161-1167

[8] α-glucosidase and glycation inhibitory effects of costus speciosus leaves [J].

Perera, Handunge Kumudu Irani ;

Premadasa, Walgama Kankanamlage Vindhya Kalpani ;

Poongunran, Jeyakumaran .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 16

[9] Antimicrobial constituents of Hypocrea virens, an endophyte of the mangrove-associate plant Premna serratifolia L. [J].

Ratnaweera, Pamoda B. ;

de Silva, E. Dilip ;

Wijesundera, Ravi L. C. ;

Andersen, Raymond J. .

JOURNAL OF THE NATIONAL SCIENCE FOUNDATION OF SRI LANKA, 2016, 44 (01) :43-51

[10] Antimicrobial activities of endophytic fungi obtained from the arid zone invasive plant Opuntia dillenii and the isolation of equisetin, from endophytic Fusarium sp. [J].

Ratnaweera, Pamoda B. ;

de Silva, E. Dilip ;

Williams, David E. ;

Andersen, Raymond J. .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 15

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