Well-Defined Air-Stable Palladium HASPO Complexes for Efficient Kumada-Corriu Cross-Couplings of (Hetero)Aryl or Alkenyl Tosylates

被引：71

作者：

Ackermann, Lutz ^{[1
]}

Kapdi, Anant R. ^{[1
]}

Fenner, Sabine ^{[1
]}

Kornhaass, Christoph ^{[1
]}

Schulzke, Carola ^{[2
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Trinity Coll Dublin, Sch Chem, Dublin 2, Ireland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 10期

关键词：

catalysis; cross-coupling; ligand; palladium; tosylate; H BOND ACTIVATION; CATALYZED DIRECT ARYLATIONS; C-H; PHOSPHINOUS ACID; SUZUKI-MIYAURA; ARYL CHLORIDES; GRIGNARD-REAGENTS; HALOGENATED NITROGEN; INDOLE SYNTHESES; CARBON-OXYGEN;

D O I：

10.1002/chem.201002386

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium complexes of representative heteroatom-substituted secondary phosphine oxide (HASPO) pre-ligands were synthesized and fully characterized, including X-ray crystal structure analysis. Importantly, these well-defined complexes served as highly efficient catalysts for Kumada-Corriu cross-coupling reactions of aryl, alkenyl, and even heteroaryl tosylates. Particularly, an air-stable catalyst derived from inexpensive PinP(O)H displayed a remarkably high catalytic efficacy, which resulted in cross-couplings at low catalyst loadings under exceedingly mild reaction conditions with ample scope.

引用

页码：2965 / 2971

页数：7

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