Organocatalytic Enantioselective Direct Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactam to β-Acyl Acrylates and 1,2-Diacylethylenes

被引：37

作者：

Chen, Yi-Ru ^{[1
]}

Das, Utpal ^{[2
]}

Liu, Meng-Hsien ^{[1
]}

Lin, Wenwei ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 11677, Taiwan

[2] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 03期

关键词：

MANNICH-TYPE; ALDOL; BUTENOLIDES; ISATINS; LACTAM; AMINO;

D O I：

10.1021/jo5027047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient Michael addition of alpha,beta-unsaturated gamma-butyrolactam to various beta-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.

引用

页码：1985 / 1992

页数：8

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