PEP4LEP study protocol: integrated skin screening and SDR-PEP administration for leprosy prevention: comparing the effectiveness and feasibility of a community-based intervention to a health centre-based intervention in Ethiopia, Mozambique and Tanzania

被引：23

作者：

Schoenmakers, Anne ^{[1
]}

Hambridge, Thomas ^{[2
]}

van Wijk, Robin ^{[1
]}

Kasang, Christa ^{[3
]}

Richardus, Jan Hendrik ^{[2
]}

Bobosha, Kidist ^{[4
]}

Mitano, Fernando ^{[5
,6
]}

Mshana, Stephen E. ^{[7
]}

Mamo, Ephrem ^{[4
]}

Marega, Abdoulaye ^{[5
]}

Mwageni, Nelly ^{[7
]}

Letta, Taye ^{[8
]}

Muloliwa, Artur Manuel ^{[5
,6
]}

Kamara, Deus Vedastus ^{[9
]}

Eman, Ahmed Mohammed ^{[10
]}

Raimundo, Litos ^{[11
]}

Njako, Blasdus ^{[12
]}

Mieras, Liesbeth ^{[1
]}

机构：

[1] NLR, Med Tech Dept, Amsterdam, Netherlands

[2] Univ Med Ctr Rotterdam, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands

[3] Deutsch Lepra & TB Hilfe eV, Wurzburg, Germany

[4] Armauer Hansen Res Inst, Addis Ababa, Ethiopia

[5] Lurio Univ, Nampula, Mozambique

[6] Minist Hlth Mozambique, Nampula Prov Hlth Directorate, Maputo, Mozambique

[7] Catholic Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Mwanza, Tanzania

[8] Minist Hlth Ethiopia, Addis Ababa, Ethiopia

[9] Minist Hlth Tanzania, Dodoma, Tanzania

[10] Deutsch Lepra & TB Hilfe eV Ethiopia, Addis Ababa, Ethiopia

[11] NLR Mozambique, Nampula, Mozambique

[12] Deutsch Lepra & TB Hilfe eV Tanzania, Dar Es Salaam, Tanzania

来源：

BMJ OPEN | 2021年 / 11卷 / 08期

基金：

欧盟地平线“2020”;

关键词：

public health; infectious diseases & infestations; tropical medicine; INCIDENTAL FINDINGS; CONTACTS; DELAY; DISEASE; CHEMOPROPHYLAXIS; DERMATOLOGY; BANGLADESH; RIFAMPICIN; DIAGNOSIS; DISTANCE;

D O I：

10.1136/bmjopen-2020-046125

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction Leprosy, or Hansen's disease, remains a cause of preventable disability. Early detection, treatment and prevention are key to reducing transmission. Post-exposure prophylaxis with single-dose rifampicin (SDR-PEP) reduces the risk of developing leprosy when administered to screened contacts of patients. This has been adopted in the WHO leprosy guidelines. The PEP4LEP study aims to determine the most effective and feasible method of screening people at risk of developing leprosy and administering chemoprophylaxis to contribute to interrupting transmission. Methods and analysis PEP4LEP is a cluster-randomised implementation trial comparing two interventions of integrated skin screening combined with SDR-PEP distribution to contacts of patients with leprosy in Ethiopia, Mozambique and Tanzania. One intervention is community-based, using skin camps to screen approximately 100 community contacts per leprosy patient, and to administer SDR-PEP when eligible. The other intervention is health centre-based, inviting household contacts of leprosy patients to be screened in a local health centre and subsequently receive SDR-PEP when eligible. The mobile health (mHealth) tool SkinApp will support health workers' capacity in integrated skin screening. The effectiveness of both interventions will be compared by assessing the rate of patients with leprosy detected and case detection delay in months, as well as feasibility in terms of cost-effectiveness and acceptability. Ethics and dissemination Ethical approval was obtained from the national ethical committees of Ethiopia (MoSHE), Mozambique (CNBS) and Tanzania (NIMR/MoHCDEC). Study results will be published open access in peer-reviewed journals, providing evidence for the implementation of innovative leprosy screening methods and chemoprophylaxis to policymakers.

引用

页数：13

共 112 条

[51]

InfoNTD, INFONTD INF CROSS CU

[52] How to (or Not to) Integrate Vertical Programmes for the Control of Major Neglected Tropical Diseases in Sub-Saharan Africa [J].