Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines

被引：1

作者：

Alghamdi, Youssef Saeed ^{[1
]}

Saleh, Osama Moseilhy ^{[2
,3
]}

Alqadri, Nada ^{[1
]}

Mashraqi, Mutaib Mosaued ^{[4
]}

Bahattab, Omar ^{[5
]}

Awad, Nabil Saied ^{[3
,6
]}

机构：

[1] Taif Univ, Turabah Univ Coll, Dept Biol, At Taif 21995, Saudi Arabia

[2] Egyptian Atom Energy Author, Nat Prod Res Dept, Natl Ctr Radiat Res & Technol NCRRT, Cairo 9621, Egypt

[3] Misr Univ Sci & Technol, Coll Biotechnol, Giza 12563, Egypt

[4] Najran Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Najran 61441, Saudi Arabia

[5] Univ Tabuk, Fac Sci, Dept Biol, Tabuk 71497, Saudi Arabia

[6] Aswan Univ, Fac Agr & Nat Resources, Dept Genet, Aswan 81528, Egypt

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2021年 / 43卷 / 03期

关键词：

Ducrosia flabellifolia; Savignya parviflora; anti-cancer; colon cancer; prostate cancer; gene expression; BCL-2; PHOSPHORYLATION; BIOACTIVE COMPOUNDS; COLORECTAL-CANCER; APOPTOSIS; ANTIOXIDANT; INDUCTION; P53; ASSOCIATION; ANTICANCER; ARREST;

D O I：

10.3390/cimb43030107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The goal of this study was to investigate whether Ducrosia flabellifolia and Savignya parviflora methanol extract the have effect on colon and prostate cancer cell lines. Analysis of total content of phenolics and flavonoids of each plant extract was carried out. Cytotoxic effect, cell cycle analysis, induction of apoptosis and gene expression of Bcl-2 and Bax genes were studied. Obtained results indicated that, the plant extracts exhibit growth inhibition of used cancer cell lines and induced apoptosis as well as arresting of cell cycle. At the molecular level, changes in gene expression were detected via qPCR and confirmed by western blotting. The exhibited anticancer potentialities of plant extracts against utilized cancer cell lines are due to its containing bioactive compounds. Further detailed isolation, fractionation and characterization of bioactive compounds are needed.

引用

页码：1518 / 1528

页数：11

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