The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

被引：14

作者：

Broedbaek, Kasper ^{[1
,2
]}

Siersma, Volkert ^{[3
]}

Andersen, Jon T. ^{[1
,2
]}

Petersen, Morten ^{[1
,2
]}

Afzal, Shoaib ^{[1
,2
]}

Hjelvang, Brian ^{[1
,2
]}

Weimann, Allan ^{[1
,2
]}

Semba, Richard D. ^{[4
]}

Ferrucci, Luigi ^{[5
]}

Poulsen, Henrik E. ^{[1
,2
,6
]}

机构：

[1] Rigshosp, Lab Clin Pharmacol Q7642, DK-2200 Copenhagen, Denmark

[2] Bispebjerg Hosp, Dept Clin Pharmacol, DK-2400 Copenhagen, Denmark

[3] Univ Copenhagen, Dept Publ Hlth, Sect Gen Practice, Res Unit Gen Practice, Copenhagen, Denmark

[4] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[5] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA

[6] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark

来源：

FREE RADICAL RESEARCH | 2011年 / 45卷 / 04期

关键词：

DNA oxidation; inflammation; iron; 8-hydroxy-2 '-deoxyguanosine; 8-oxo-7,8-dihydro-2 '-deoxyguanosine; 8-oxodG; 8-oxo-7,8-dihydroguanosine; 8-oxoGuo; C-REACTIVE PROTEIN; HELICOBACTER-PYLORI INFECTION; CORONARY-HEART-DISEASE; DNA-DAMAGE; BODY IRON; HEALTHY PEOPLE; STRESS; CANCER; WOMEN; MEN;

D O I：

10.3109/10715762.2010.538391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.

引用

页码：409 / 416

页数：8

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