The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

被引：14

作者：

Broedbaek, Kasper ^{[1
,2
]}

Siersma, Volkert ^{[3
]}

Andersen, Jon T. ^{[1
,2
]}

Petersen, Morten ^{[1
,2
]}

Afzal, Shoaib ^{[1
,2
]}

Hjelvang, Brian ^{[1
,2
]}

Weimann, Allan ^{[1
,2
]}

Semba, Richard D. ^{[4
]}

Ferrucci, Luigi ^{[5
]}

Poulsen, Henrik E. ^{[1
,2
,6
]}

机构：

[1] Rigshosp, Lab Clin Pharmacol Q7642, DK-2200 Copenhagen, Denmark

[2] Bispebjerg Hosp, Dept Clin Pharmacol, DK-2400 Copenhagen, Denmark

[3] Univ Copenhagen, Dept Publ Hlth, Sect Gen Practice, Res Unit Gen Practice, Copenhagen, Denmark

[4] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[5] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA

[6] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark

来源：

FREE RADICAL RESEARCH | 2011年 / 45卷 / 04期

关键词：

DNA oxidation; inflammation; iron; 8-hydroxy-2 '-deoxyguanosine; 8-oxo-7,8-dihydro-2 '-deoxyguanosine; 8-oxodG; 8-oxo-7,8-dihydroguanosine; 8-oxoGuo; C-REACTIVE PROTEIN; HELICOBACTER-PYLORI INFECTION; CORONARY-HEART-DISEASE; DNA-DAMAGE; BODY IRON; HEALTHY PEOPLE; STRESS; CANCER; WOMEN; MEN;

D O I：

10.3109/10715762.2010.538391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.

引用

页码：409 / 416

页数：8

共 32 条

[1] Baseline C-Reactive Protein Is Associated With Incident Cancer and Survival in Patients With Cancer [J].

Allin, Kristine H. ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (13) :2217-2224

[2] Increased DNA damage and oxidative stress in patients with rheumatoid arthritis [J].

Altindag, Ozlem ;

Karakoc, Mehmet ;

Kocyigit, Abdurrahim ;

Celik, Hakim ;

Soran, Neslihan .

CLINICAL BIOCHEMISTRY, 2007, 40 (3-4) :167-171

[3] Phagocytes and oxidative stress [J].

Babior, BM .

AMERICAN JOURNAL OF MEDICINE, 2000, 109 (01) :33-44

[4] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[5] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[6] C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: The EPIC-Norfolk prospective population study 1993-2003 [J].

Boekholdt, S. Matthijs ;

Hack, C. Erik ;

Sandhu, Manjinder S. ;

Luben, Robert ;

Bingham, Sheila A. ;

Wareham, Nicholas J. ;

Peters, Ron J. G. ;

Jukema, J. Wouter ;

Day, Nicholas E. ;

Kastelein, John J. P. ;

Khaw, Kay-Tee .

ATHEROSCLEROSIS, 2006, 187 (02) :415-422

[7] Relationship between levels of DNA damage in lymphocytes and histopathological severity of chronic hepatitis C and various clinical forms of hepatitis B [J].

Bolukbas, C ;

Bolukbas, FF ;

Kocyigit, A ;

Aslan, M ;

Selek, S ;

Bitiren, M ;

Ulukanligil, M .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2006, 21 (03) :610-616

[8] Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis [J].

Broedbaek, Kasper ;

Poulsen, Henrik E. ;

Weimann, Allan ;

Kom, Ghainsom D. ;

Schwedhelm, Edzard ;

Nielsen, Peter ;

Boeger, Rainer H. .

FREE RADICAL BIOLOGY AND MEDICINE, 2009, 47 (08) :1230-1233

[9] Impact of radiotherapy and chemotherapy on biomarkers of oxidative DNA damage in lung cancer patients [J].

Crohns, Marika ;

Saarelainen, Seppo ;

Erhola, Marina ;

Alho, Hannu ;

Kellokumpu-Lehtinen, Pirkko .

CLINICAL BIOCHEMISTRY, 2009, 42 (10-11) :1082-1090

[10] Lymphocyte DNA damage in patients with acute coronary syndrome and its relationship with severity of acute coronary syndrome [J].

Demirbag, R ;

Yilmaz, R ;

Gur, M ;

Kocyigit, A ;

Celik, H ;

Guzel, S ;

Selek, S .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 578 (1-2) :298-307

← 1 2 3 4 →