miRSNP-Based Approach Identifies a miRNA That Regulates Prostate-Specific Antigen in an Allele-Specific Manner

被引：9

作者：

Yousef, George M. ^{[1
,2
,3
]}

机构：

[1] St Michaels Hosp, Li Ka Shing Knowledge Inst, Dept Lab Med, Toronto, ON M5B1T8, Canada

[2] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Sci, Toronto, ON M5B1T8, Canada

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

CANCER DISCOVERY | 2015年 / 5卷 / 04期

关键词：

CANCER; TRAITS; LOCI;

D O I：

10.1158/2159-8290.CD-15-0230

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A recent study identified genetic variations within the miRNA response elements of miRNA target genes (miRSNP) that can affect the base paring between miRNAs and their targets, and hence alter miRNA-target interactions. The authors also undertook functional validation studies and were able to demonstrate that overexpression of miR-3162-5p resulted in a 20% decrease in expression of the KLK3 rs1058205 SNP T-allele. (C) 2015 AACR.

引用

页码：351 / 352

页数：2

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