Clonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases

被引：13

作者：

Herens, C

Baron, F

Croisiau, C

Tassin, F

Bours, V

机构：

[1] Univ Liege, CHU Sart Tilman, Ctr Human Genet, B-4000 Sart Tilman Par Liege, Belgium

[2] Univ Liege, Div Hematol, Dept Med, B-4000 Sart Tilman Par Liege, Belgium

[3] Hop St Joseph, Dept Haematol Lab, Liege, Belgium

[4] Univ Liege, Dept Biol Clin, Div Lab Hematol, Liege, Belgium

来源：

CANCER GENETICS AND CYTOGENETICS | 2003年 / 147卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(03)00198-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Imatinib mesylate (tested as ST1571), an ab1 kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal chromosomal aberrations in Philadelphia-negative (Ph-) cells during treatment has been reported. We describe two CML patients in chronic phase who presented with complete cytogenetic responses during imatinib mesylate therapy but developed new clonal chromosomal rearrangements in Ph- cells. The first patient presented with a duplication of chromosome 1, dup(l)(q21q42), and the second showed two new clonal aberrations consisting of inv(l)(q12q32) and del(7)(q22) in the same clone. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：78 / 80

页数：3

共 15 条

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