A time to fast

被引：343
作者：
Di Francesco, Andrea [1 ]
Di Germanio, Clara [1 ]
Bernier, Michel [1 ]
de Cabo, Rafael [1 ]
机构：
[1] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA
来源：
SCIENCE | 2018年 / 362卷 / 6416期
关键词：
REDUCED MEAL FREQUENCY; CALORIC RESTRICTION; LIFE-SPAN; DIETARY RESTRICTION; CONTROLLED-TRIAL; IMPROVES HEALTH; NORMAL-WEIGHT; BODY-WEIGHT; LONGEVITY; HUMANS;
D O I：
10.1126/science.aau2095
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nutrient composition and caloric intake have traditionally been used to devise optimized diets for various phases of life. Adjustment of meal size and frequency have emerged as powerful tools to ameliorate and postpone the onset of disease and delay aging, whereas periods of fasting, with or without reduced energy intake, can have profound health benefits. The underlying physiological processes involve periodic shifts of metabolic fuel sources, promotion of repair mechanisms, and the optimization of energy utilization for cellular and organismal health. Future research endeavors should be directed to the integration of a balanced nutritious diet with controlled meal size and patterns and periods of fasting to develop better strategies to prevent, postpone, and treat the socioeconomical burden of chronic diseases associated with aging.
引用
收藏
页码：770 / 775
页数：6
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