surgery;
replacement therapy;
factor VII deficiency;
D O I:
10.1111/j.1365-2141.2010.08287.x
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
P>Excessive bleeding represents a major complication of surgical interventions and its control is especially relevant in patients with Congenital Bleeding Disorders (CBD). In factor VII (FVII) deficiency, scanty data on surgery is available to guide treatment strategies. The STER (Seven Treatment Evaluation Registry) is a multi-centre, prospective, observational, web-based study protocol providing the frame for a structured and detailed data collection. Inhibitor occurrence was checked in a centralized fashion. Forty-one surgical operations (24 'major' and 17 'minor') were performed in 34 subjects with a carefully characterized FVII deficiency under the coverage of recombinant activated Factor VII (rFVIIa). Bleeding occurred during three major interventions of orthopaedic surgery, but rFVIIa was given at very low dose in each case. An antibody to FVII was observed in one patient who underwent a multiple dental extraction. No thromboses were reported during the 30-d follow up period. Replacement therapy with rFVIIa proved effective when suitable doses were used, which, during the period of maximum bleeding risk (the day of operation), were calculated (Receiver Operated Characteristic analysis) to be of at least 13 mu g/kg/body weight per single dose and no less than three administrations. This indication is important especially in the case of major surgery.
机构:
Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Herrmann, F. H.
;
Wulff, K.
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h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Wulff, K.
;
Auerswald, G.
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h-index: 0
机构:
Prof Hess Children Hosp Bremen, Bremen, GermanyErnst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Auerswald, G.
;
Schulman, S.
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机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Schulman, S.
;
Astermark, J.
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机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Astermark, J.
;
Batorova, A.
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h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Batorova, A.
;
Kreuz, W.
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机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Kreuz, W.
;
Pollmann, H.
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h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Pollmann, H.
;
Ruiz-Saez, A.
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h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Ruiz-Saez, A.
;
De Bosch, N.
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h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
De Bosch, N.
;
Salazar-Sanchez, L.
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h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
机构:
Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Herrmann, F. H.
;
Wulff, K.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Wulff, K.
;
Auerswald, G.
论文数: 0引用数: 0
h-index: 0
机构:
Prof Hess Children Hosp Bremen, Bremen, GermanyErnst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Auerswald, G.
;
Schulman, S.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Schulman, S.
;
Astermark, J.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Astermark, J.
;
Batorova, A.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Batorova, A.
;
Kreuz, W.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Kreuz, W.
;
Pollmann, H.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Pollmann, H.
;
Ruiz-Saez, A.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
Ruiz-Saez, A.
;
De Bosch, N.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany
De Bosch, N.
;
Salazar-Sanchez, L.
论文数: 0引用数: 0
h-index: 0
机构:Ernst Moritz Arndt Univ Greifswald, Fac Med, Inst Human Genet, D-17487 Greifswald, Germany