Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results

被引：3

作者：

Alterio, Daniela ^{[1
]}

Tagliabue, Marta ^{[2
]}

Muto, Matteo ^{[1
]}

Zorzi, Stefano ^{[2
]}

Volpe, Stefania ^{[1
]}

Gandini, Sara ^{[3
]}

Sibio, Daniela ^{[1
,4
]}

Bayir, Omer ^{[2
,5
]}

Marvaso, Giulia ^{[1
]}

Ferrari, Annamaria ^{[1
]}

Bruschini, Roberto ^{[2
]}

Rocca, Maria Cossu ^{[6
]}

Preda, Lorenzo ^{[7
,8
]}

Marangoni, Roberta ^{[2
]}

Starzynska, Anna ^{[9
]}

Vigorito, Sabrina ^{[10
]}

Ansarin, Mohssen ^{[2
]}

Jereczek-Fossa, Barbara Alicja ^{[1
,4
]}

机构：

[1] IEO, Dept Radiotherapy, IRCCS, European Inst Oncol, Milan, Italy

[2] IEO, Div Otolaryngol & Head & Neck Surg, IRCCS, European Inst Oncol, Milan, Italy

[3] IEO, Dept Expt Oncol, IRCCS, European Inst Oncol, Milan, Italy

[4] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy

[5] Diskapi Yildirim Beyazit Res & Training Hosp, Otolaryngol & Head & Neck Surg, Ankara, Turkey

[6] IEO, Med Oncol Div Urogenital & Head & Neck Tumours, IRCCS, European Inst Oncol, Milan, Italy

[7] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

[8] Natl Ctr Oncol Hadrontherapy CNAO, Diagnost Imaging Unit, Pavia, Italy

[9] Med Univ Gdansk, Dept Oral Surg, Gdansk, Poland

[10] IEO, Unit Med Phys, IRCCS, European Inst Oncol, Milan, Italy

来源：

TUMORI JOURNAL | 2020年 / 106卷 / 06期

关键词：

Oropharyngeal cancer; postoperative radiotherapy; soft tissue necrosis; supraglottic laryngeal cancer; transoral robotic surgery; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; QUALITY-OF-LIFE; OROPHARYNGEAL CANCER; RADIATION-THERAPY; FUNCTIONAL OUTCOMES; LATERAL OROPHARYNGECTOMY; ADJUVANT RADIATION; NECK CANCERS; CHEMOTHERAPY;

D O I：

10.1177/0300891619900920

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes (p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.

引用

页码：471 / 479

页数：9

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