N-acetylcysteine and ascorbic acid therapy for acute hepatic injury after hexavalent chromium ingestion

被引：6

作者：

Yu, Jiun-Hao ^{[1
,2
]}

Lu, Jian-Xun ^{[2
]}

Smollin, Craig ^{[3
]}

Cheng, Hao-Tsai ^{[4
]}

Seak, Chen-June ^{[2
]}

Chen, Hsien-Yi ^{[2
]}

机构：

[1] China Med Univ Hosp, Dept Emergency Med, Hsinchu, Taiwan

[2] Chang Gung Mem Hosp, Dept Emergency Med, Linkou Branch, Taoyuan, Taiwan

[3] Univ Calif San Francisco, Dept Emergency Med, San Francisco, CA 94143 USA

[4] Chang Gung Mem Hosp, Dept Internal Med, Linkou Branch, Taoyuan, Taiwan

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2020年 / 45卷 / 01期

关键词：

ascorbic acid; hepatic injury; hexavalent chromium poisoning; N-acetylcysteine; REDUCTION;

D O I：

10.1111/jcpt.13044

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objective Hexavalent (VI) chromium is a powerful oxidant that can produce cellular oxidative stress and multi-organ system dysfunction. The role of antioxidants such as N-acetylcysteine (NAC) and ascorbic acid in alleviating organ damage in humans remains unclear. Case description We present a 47-year-old male who ingested 30 mL of plating solution and developed hepatic injury. He was treated with NAC and ascorbic acid with improvement in hepatic function. However, his clinical conditions and jaundice worsened again after discontinuing these therapies. What is new and conclusion Our findings suggest a potential role for antioxidant therapy for acute hexavalent chromium poisoning.

引用

页码：208 / 210

页数：3

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