Ultra-Low-Dose Recombinant Human Bone Morphogenetic Protein-2 for 3-Level Anterior Cervical Diskectomy and Fusion

被引：7

作者：

Pourtaheri, Sina ^{[1
]}

Hwang, Ki ^{[1
]}

Faloon, Michael ^{[1
]}

Issa, Kimona ^{[1
]}

Mease, Samuel J. ^{[1
]}

Mangels, Daniel ^{[1
]}

Sinha, Kumar ^{[1
]}

Emami, Arash ^{[1
]}

机构：

[1] Seton Hall Univ, Sch Hlth & Med Sci, St Josephs Reg Med Ctr, Dept Orthoped Surg, Paterson, NJ 07503 USA

来源：

ORTHOPEDICS | 2015年 / 38卷 / 04期

关键词：

LUMBAR INTERBODY FUSION; SPINE SURGERY; RHBMP-2; DYSPHAGIA; OUTCOMES; COMPLICATIONS; AUTOGRAFT; RISK;

D O I：

10.3928/01477447-20150402-04

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

This study evaluated the safety of 3-level anterior cervical diskectomy and fusion (ACDF) with ultra-low-dose recombinant bone morphogenetic protein-2 (rhBMP-2). Thirty-seven consecutive patients with cervical spondylotic myelopathy who were treated with 3-level ACDF and rhBMP-2 were evaluated. Complications such as airway or cervical swelling or hematoma were not observed. The rate of dysphagia was no different at 1, 2, and 6 months postoperatively compared with reports in the literature without rhBMP-2. There were significant improvements in VAS neck/arm pain, Oswestry Neck Disability Index, and cervical lordosis. The use of ultra-low-dose rhBMP-2 for 3-level ACDF may be efficacious for surgically addressing 3-level spondylotic myelopathy.

引用

收藏

页码：241 / 245

页数：5

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