Ultra-Low-Dose Recombinant Human Bone Morphogenetic Protein-2 for 3-Level Anterior Cervical Diskectomy and Fusion

被引：7
作者：
Pourtaheri, Sina [1 ]
Hwang, Ki [1 ]
Faloon, Michael [1 ]
Issa, Kimona [1 ]
Mease, Samuel J. [1 ]
Mangels, Daniel [1 ]
Sinha, Kumar [1 ]
Emami, Arash [1 ]
机构：
[1] Seton Hall Univ, Sch Hlth & Med Sci, St Josephs Reg Med Ctr, Dept Orthoped Surg, Paterson, NJ 07503 USA
来源：
ORTHOPEDICS | 2015年 / 38卷 / 04期
关键词：
LUMBAR INTERBODY FUSION; SPINE SURGERY; RHBMP-2; DYSPHAGIA; OUTCOMES; COMPLICATIONS; AUTOGRAFT; RISK;
D O I：
10.3928/01477447-20150402-04
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
This study evaluated the safety of 3-level anterior cervical diskectomy and fusion (ACDF) with ultra-low-dose recombinant bone morphogenetic protein-2 (rhBMP-2). Thirty-seven consecutive patients with cervical spondylotic myelopathy who were treated with 3-level ACDF and rhBMP-2 were evaluated. Complications such as airway or cervical swelling or hematoma were not observed. The rate of dysphagia was no different at 1, 2, and 6 months postoperatively compared with reports in the literature without rhBMP-2. There were significant improvements in VAS neck/arm pain, Oswestry Neck Disability Index, and cervical lordosis. The use of ultra-low-dose rhBMP-2 for 3-level ACDF may be efficacious for surgically addressing 3-level spondylotic myelopathy.
引用
收藏
页码：241 / 245
页数：5
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