Supportive therapy in gastroenteropancreatic neuroendocrine tumors: Often forgotten but important

被引：20

作者：

Jin, Xi-Feng ^{[1
]}

Spampatti, Matilde P. ^{[2
,3
]}

Spitzweg, Christine ^{[1
,3
]}

Auernhammer, Christoph J. ^{[1
,3
]}

机构：

[1] Ludwig Maximilian Univ Munich, Dept Internal Med 4, Univ Hosp Campus Grosshadern, Munich, Germany

[2] Ludwig Maximilian Univ Munich, Dept Internal Med 2, Univ Hosp Campus Grosshadern, Munich, Germany

[3] Ludwig Maximilians Univ Munchen, Interdisciplinary Ctr Neuroendocrine Tumours Gast, Klinikum Univ Muenchen, Campus Grosshadern,Marchioninistr 15, D-81377 Munich, Germany

来源：

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2018年 / 19卷 / 02期

关键词：

Neuroendocrine tumors (NETs); Gastroenteropancreatic neuroendocrine tumours (GEP-NETs); Supportive therapy; hypersecretion syndromes; carcinoid syndrome (CS); ENETS CONSENSUS GUIDELINES; CARCINOID HEART-DISEASE; INTESTINAL BACTERIAL OVERGROWTH; CLINICAL-PRACTICE GUIDELINE; QUALITY-OF-LIFE; RECEPTOR RADIONUCLIDE THERAPY; ZOLLINGER-ELLISON SYNDROME; BILE-ACID DIARRHEA; TELOTRISTAT ETHYL; TRANSCATHETER PULMONARY;

D O I：

10.1007/s11154-018-9443-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neuroendocrine tumors (NETs) are a group of rare and heterogeneous malignancies that can develop in various organs. A significant number of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is functionally active and presents with symptoms related to the secretion of biologically active substances, leading to the development of distinct clinical syndromes. There are various therapeutic approaches for GEP-NETs, including curative surgery, palliative surgery, local-ablative and loco-regional therapies as well as systemic therapeutic options including peptide receptor radionuclide therapy, cytotoxic therapy, and molecularly targeted therapies. Specific supportive therapy of patients with NETs includes management or prevention of hormone-related clinical syndromes and paraneoplastic states. Supportive therapy plays a key role in NET treatment. Supportive therapy includes debulking surgery and interventional radiologic techniques to reduce tumour bulk or load, as well as systemic medical treatment options to manage or prevent hypersecretion syndromes and treatment-related side effects. Supportive therapies are a type of of comprehensive treatment addressing the patient as a whole person throughout the process of NET treatment. Therefore, supportive therapy also encompasses psychosocial support, expert nursing, nutritional support and management of cancer related pain.

引用

页码：145 / 158

页数：14

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