Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer

被引：17

作者：

Guan, Sisi ^{[1
]}

Li, Li ^{[1
]}

Chen, Wen-Shu ^{[2
]}

Jiang, Wen-Yang ^{[3
]}

Ding, Yun ^{[2
]}

Zhao, Li-Lan ^{[2
]}

Shi, Yi-Fan ^{[4
]}

Wang, Jun ^{[4
]}

Gui, Qi ^{[4
]}

Xu, Cheng-Cheng ^{[5
]}

Cheng, Yang ^{[1
]}

Zhang, Wenjuan ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Geriatr, Wuhan, Peoples R China

[2] Fujian Med Univ, Dept Thorac Surg, Shengli Clin Med Coll, Fuzhou, Peoples R China

[3] Wuhan Univ, Dept Thorac Surg, Renmin Hosp, Wuhan, Peoples R China

[4] Soochow Univ, Dept Thorac Surg, Affiliated Hosp 1, Suzhou, Peoples R China

[5] Soochow Univ, Dept Oncol, Affiliated Hosp 1, Suzhou, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2021年 / 25卷 / 20期

关键词：

circ-WHSC1; miR-7; non-small cell lung cancer; TAB2; NF-KAPPA-B; GROWTH-FACTOR RECEPTOR; ADAPTER PROTEIN; TAB2; TAK1; EXPRESSION; KINASE; CELLS; ACTIVATION; BIOMARKER;

D O I：

10.1111/jcmm.16925

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Circular RNA is a newly discovered member of non-coding RNA (ncRNA) and regulates the target gene by acting as a micro-RNA sponge. It plays vital roles in various diseases. However, the functions of circular RNA in non-small cell lung cancer (NSCLC) remain still unclear. Our data showed that circ-WHSC1 was highly expressed in NSCLC cells and tissues. Both in vitro and in vivo experiments showed that circ-WHSC1 promoted NSCLC proliferation. circ-WHSC1 also promoted the migration and invasion of lung cancer cells. Through bioinformatic analysis and functional experiments, we showed that circ-WHSC1 could act as a sponge for micro-RNA-7 (miR-7) and regulate the expression of TAB2 (TGF-beta activated kinase one binding protein two). Inhibition of the circ-WHSC1/miR-7/TAB2 pathway could effectively attenuate lung cancer progression. In summary, this study confirmed the existence and oncogenic function of circ-WHSC1 in NSCLC. The research suggests that the circ-WHSC1/miR-7/TAB2 axis might be a potential target for NSCLC therapy.

引用

页码：9784 / 9795

页数：12

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