Segmented polyurethane elastomers derived from aliphatic polycarbonate and poly(ester-carbonate) soft segments for biomedical applications

被引：35

作者：

Sobczak, Marcin ^{[1
]}

Debek, Cezary ^{[2
]}

Oledzka, Ewa ^{[1
]}

Nalecz-Jawecki, Grzegorz ^{[3
]}

Kolodziejski, Waclaw L. ^{[1
]}

Rajkiewicz, Maria ^{[2
]}

机构：

[1] Med Univ Warsaw, Dept Inorgan & Analyt Chem, Fac Pharm, PL-02097 Warsaw, Poland

[2] Inst Engn Polymer Mat & Dies, Dept Technol Composite Mat, PL-87100 Torun, Poland

[3] Med Univ Warsaw, Fac Pharm, Dept Environm Hlth Sci, PL-02097 Warsaw, Poland

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2012年 / 50卷 / 18期

关键词：

biomedical polymers; polycarbonates; polyesters; polymeric biomaterials; polyurethanes; RING-OPENING POLYMERIZATION; MOLECULAR-WEIGHT; POLY(CARBONATE-URETHANE); POLYESTERS; LACTONES; LACTIDE; DIOLS;

D O I：

10.1002/pola.26190

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A series of biomedical polyurethane elastomers (PURs) based on poly(ester-carbonate)s (PECs) and polycarbonates (PCs) were synthesized and spectrally characterized fully. PEC or PC diols were synthesized by the ring-opening polymerization of e-caprolactone, trimethylene carbonate, and neopentyl carbonate catalyzed by lipase from Candida antarctica. PURs were prepared by free-metal method from PEC or PC diols and 4,4'-methylenebis(phenyl isocyanate), with 1,4-butanediol as a chain extender. The physical and mechanical properties as well as hydrolytic stability of the obtained PURs were determined. The toxicity of the received polymers was evaluated using bacterial luminescence test and two protozoans assays. The presented preliminary studies suggest that PEC or PC diols prepared in this way might be applied for the synthesis of biomedical PURs with improved hydrolytic stability. (c) 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

引用

页码：3904 / 3913

页数：10

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