Late graft failure 8 years after first bone marrow transplantation for severe acquired aplastic anemia

被引：10

作者：

Dufour, C

Dallorso, S

Casarino, L

Corcione, A

Pistoia, V

Bacigalupo, A

Morreale, G

Dini, G

机构：

[1] Ist Giannina Gaslini, Dept Pediat Hemato Oncol, I-16148 Genoa, Italy

[2] Ist Giannina Gaslini, Bone Marrow Transplantat Unit, I-16148 Genoa, Italy

[3] Univ Genoa, Dept Legal Med, Genoa, Italy

[4] Ist Giannina Gaslini, Lab Oncol, I-16148 Genoa, Italy

[5] Osped San Martino Genova, Dept Hematol, Genoa, Italy

来源：

BONE MARROW TRANSPLANTATION | 1999年 / 23卷 / 07期

关键词：

bone marrow transplant; aplastic anemia; graft failure; second transplant;

D O I：

10.1038/sj.bmt.1701652

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A 14-year-old patient with acquired very severe aplastic anemia (VSAA) underwent bone marrow transplantation (BMT) from his HLA-identical brother. Preparative therapy was cyclophosphamide (CY) 200 mg/kg over 4 days. GVHD prophylaxis was with cyclosporin A (CsA) for a year. After an 8 year follow-up during which the patient was well with normal blood counts, graft failure occurred. At this time marrow chimerism studies demonstrated that 85% of hemopoiesis was of recipient origin. The patient was re-engrafted from the same donor after conditioning with CY 200 mg/kg over 4 days plus rabbit antithymocyte globulin (ATG) 3.5 mg/kg/day for 3 days. After 140 days follow-up he has a normal blood count. The possible causes of the graft failure are discussed. This case demonstrates that, although rarely, very late graft failure may occur after BMT for AA and highlights the need for long-term monitoring even in apparently successfully transplanted patients.

引用

页码：743 / 745

页数：3