miRNAs in breast cancer tumorigenesis (Review)

被引：55

作者：

Zhang, Zhong Ju ^{[1
]}

Ma, Shi Liang ^{[1
]}

机构：

[1] Shenyang Agr Univ, Coll Biol Sci & Biotechnol, Shenyang 110866, Peoples R China

来源：

ONCOLOGY REPORTS | 2012年 / 27卷 / 04期

关键词：

miRNA; breast cancer; ESTROGEN-RECEPTOR-ALPHA; SELF-RENEWAL; MESENCHYMAL TRANSITION; DOWN-REGULATION; STEM-CELLS; TISSUE INHIBITOR; GENE-EXPRESSION; TUMOR INVASION; E-CADHERIN; MICRORNAS;

D O I：

10.3892/or.2011.1611

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-coding mRNAs at the post-transcriptional level. It is estimated that in humans thousands of miRNAs are expressed and more than 700 miRNAs have been described to date. About 50% of annotated human miRNAs are detected in regions of fragile sites, which are associated with cancer. The available evidence has shown that miRNAs widely participate in the development or progression of many types of cancers, including breast cancer. The role of miRNAs in breast cancer has been widely investigated; here, we will focus on what is known about the working mechanism of miRNAs in different stages of breast cancer development.

引用

页码：903 / 910

页数：8

共 93 条

[21] Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer [J].

Chang, Xin-Zhong ;

Li, Da-Qiang ;

Hou, Yi-Feng ;

Wu, Jiong ;

Lu, Jin-Song ;

Di, Gen-Hong ;

Jin, Wei ;

Ou, Zhou-Luo ;

Shen, Zhen-Zhou ;

Shao, Zhi-Ming .

BREAST CANCER RESEARCH, 2007, 9 (06)

[22] miR-15 and miR-16 induce apoptosis by targeting BCL2 [J].

Cimmino, A ;

Calin, GA ;

Fabbri, M ;

Iorio, MV ;

Ferracin, M ;

Shimizu, M ;

Wojcik, SE ;

Aqeilan, RI ;

Zupo, S ;

Dono, M ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :13944-13949

[23] Genomic analysis of metastasis reveals an essential role for RhoC [J].

Clark, EA ;

Golub, TR ;

Lander, ES ;

Hynes, RO .

NATURE, 2000, 406 (6795) :532-535

[24] miRNAs, cancer, and stem cell division [J].

Croce, CM ;

Calin, GA .

CELL, 2005, 122 (01) :6-7

[25]

Dimri GP, 2002, CANCER RES, V62, P4736

[26] miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases [J].

Dykxhoorn, Derek M. ;

Wu, Yichao ;

Xie, Huangming ;

Yu, Fengyan ;

Lal, Ashish ;

Petrocca, Fabio ;

Martinvalet, Denis ;

Song, Erwei ;

Lim, Bing ;

Lieberman, Judy .

PLOS ONE, 2009, 4 (09)

[27] Proliferation, cell cycle and apoptosis in cancer [J].

Evan, GI ;

Vousden, KH .

NATURE, 2001, 411 (6835) :342-348

[28] MiR-126 regulates angiogenic signaling and vascular integrity [J].

Fish, Jason E. ;

Santoro, Massimo M. ;

Morton, Sarah U. ;

Yu, Sangho ;

Yeh, Ru-Fang ;

Wythe, Joshua D. ;

Lvey, Kathryn N. ;

Bruneau, Benoit G. ;

Stainier, Didier Y. R. ;

Srivastava, Deepak .

DEVELOPMENTAL CELL, 2008, 15 (02) :272-284

[29] Minireview: Cyclin D1: Normal and abnormal functions [J].

Fu, MF ;

Wang, CG ;

Li, ZP ;

Sakamaki, T ;

Pestell, RG .

ENDOCRINOLOGY, 2004, 145 (12) :5439-5447

[30] MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators [J].

Gabriely, Galina ;

Wurdinger, Thomas ;

Kesari, Santosh ;

Esau, Christine C. ;

Burchard, Julja ;

Linsley, Peter S. ;

Krichevsky, Anna M. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (17) :5369-5380

← 1 2 3 4 5 6 7 8 9 10 →