Stereospecific Palladium-Catalyzed Decarboxylative C(sp3)-C(sp2) Coupling of 2,5-Cyclohexadiene-1-carboxylic Acid Derivatives with Aryl Iodides

被引：27

作者：

Chou, Chih-Ming ^{[1
]}

Chatterjee, Indranil ^{[1
]}

Studer, Armido ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 37期

关键词：

asymmetric synthesis; Birch reduction; C-C bond formation; homogeneous catalysis; palladium; KOCH-HAAF CARBOXYLATIONS; METALATED CYCLOHEXADIENES; REDUCTION-ALKYLATION; ALLYLIC ALKYLATION; BIRCH REDUCTION; DESYMMETRIZATION; ALLYLATION; OLEFINATION; HALIDES;

D O I：

10.1002/anie.201103450

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Walk on the same side! The title reaction occurs by means of highly stereospecific 1,3-metal migration. The starting carboxylic acids are readily prepared by Birch reduction, and the developed protocol provides an efficient route to enantiomerically pure 5-arylated-1,3-cyclohexadiene derivatives (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8614 / 8617

页数：4

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