Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

被引：77
作者：
Chen, Xi [1 ,2 ,3 ]
Lu, Yun [1 ,2 ,3 ]
Zhang, Zhengguo [1 ,2 ,3 ]
Wang, Jian [1 ,2 ,3 ]
Yang, Hui [1 ,2 ,3 ]
Liu, Guangwei [1 ,2 ,3 ]
机构：
[1] Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
[2] Fudan Univ, Biotherapy Res Ctr, Shanghai 200032, Peoples R China
[3] Fudan Univ, Inst Immunobiol, Shanghai 200032, Peoples R China
来源：
IMMUNOLOGY | 2015年 / 145卷 / 04期
关键词：
immune diseases; innate immune cells; myeloid-derived suppressor cells; metabolism; regulatory T cells; Sirt1; T-cell activation; NF-KAPPA-B; HUMAN-IMMUNODEFICIENCY-VIRUS; EXTENDS LIFE-SPAN; HUMAN T-CELLS; TRANSCRIPTION FACTOR; SUPPRESSOR-CELLS; INFLAMMATORY PATHWAYS; GLUCOSE-HOMEOSTASIS; INSULIN-SECRETION; INCREASED DOSAGE;
D O I：
10.1111/imm.12473
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sirtuins are evolutionarily conserved class III histone deacetylases that have been the focus of intense scrutiny and interest since the discovery of Sir2 as a yeast longevity factor. Early reports demonstrated an important role of Sirt1 in aging and metabolism, but its critical regulatory role in the immune system has only been unveiled in recent years. In this review we discuss the latest advances in understanding the regulatory role of Sirt1 in immune responses as well as how Sirt1 translates metabolic cues to immune signals, which would bring new insights into both pathogenesis and potential therapeutic strategies of a variety of immune-related diseases, such as cancer, microbial infection, autoimmune diseases and transplantation.
引用
收藏
页码：455 / 467
页数：13
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