Exploring the Clinical Utility of Pancreatic Cancer Circulating Tumor Cells

被引：40

作者：

Yeo, Dannel ^{[1
,2
,3
]}

Bastian, Althea ^{[1
,2
,3
]}

Strauss, Heidi ^{[1
,2
,3
]}

Saxena, Payal ^{[2
,4
]}

Grimison, Peter ^{[2
,5
]}

Rasko, John E. J. ^{[1
,2
,3
,6
]}

机构：

[1] Univ Sydney, Li Ka Shing Cell & Gene Therapy Program, Camperdown, NSW 2050, Australia

[2] Univ Sydney, Fac Med & Hlth, Camperdown, NSW 2050, Australia

[3] Royal Prince Alfred Hosp, Sydney Local Hlth Dist SLHD, Cell & Mol Therapies, Camperdown, NSW 2050, Australia

[4] Royal Prince Alfred Hosp, Sydney Local Hlth Dist, Dept Med, Div Gastroenterol, Camperdown, NSW 2050, Australia

[5] Chris OBrien Lifehouse, Med Oncol, Camperdown, NSW 2050, Australia

[6] Univ Sydney, Centenary Inst, Gene & Stem Cell Therapy Program, Camperdown, NSW 2050, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期

基金：

英国医学研究理事会;

关键词：

liquid biopsy; biomarker; prognosis; screening; stem cell; organoids; precision medicine; personalized medicine; EUS-GUIDED FNA; EPITHELIAL-CELLS; PROGNOSTIC VALUE; PERIPHERAL-BLOOD; CARCINOEMBRYONIC ANTIGEN; MESENCHYMAL TRANSITION; BREAST-CANCER; RT-PCR; SURVIVAL; DIAGNOSIS;

D O I：

10.3390/ijms23031671

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is the most frequent pancreatic cancer type, characterized by a dismal prognosis due to late diagnosis, frequent metastases, and limited therapeutic response to standard chemotherapy. Circulating tumor cells (CTCs) are a rare subset of tumor cells found in the blood of cancer patients. CTCs has the potential utility for screening, early and definitive diagnosis, prognostic and predictive assessment, and offers the potential for personalized management. However, a gold-standard CTC detection and enrichment method remains elusive, hindering comprehensive comparisons between studies. In this review, we summarize data regarding the utility of CTCs at different stages of PDAC from early to metastatic disease and discuss the molecular profiling and culture of CTCs. The characterization of CTCs brings us closer to defining the specific CTC subpopulation responsible for metastasis with the potential to uncover new therapies and more effective management options for PDAC.

引用

页数：18

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