Ru(II)-Catalyzed Amination of Aryl Fluorides via η6-Coordination

被引：48

作者：

Kang, Qi-Kai ^{[1
,2
]}

Lin, Yunzhi ^{[1
,2
]}

Li, Yuntong ^{[1
,2
]}

Shi, Hang ^{[1
,2
]}

机构：

[1] Westlake Inst Adv Study, Inst Nat Sci, Hangzhou 310024, Zhejiang, Peoples R China

[2] Westlake Univ, Sch Sci, Key Lab Precise Synth Funct Mol Zhejiang Prov, Hangzhou 310024, Zhejiang, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 08期

基金：

中国博士后科学基金;

关键词：

NUCLEOPHILIC AROMATIC-SUBSTITUTION; EXCHANGE-REACTIONS; CATALYTIC SNAR; BOND FORMATION; N-ARYLATION; ACTIVATION; COMPLEXES; FLUOROARENES; DERIVATIVES; CLEAVAGE;

D O I：

10.1021/jacs.9b13684

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed a Ru/hemilabile-ligand-catalyzed nucleophilic aromatic substitution (SNAr) of aryl fluorides as the limiting reagents. Significant ligand enhancement was demonstrated by the engagement of both electron-rich and neutral arenes in the SNAr amination without using excess arenes. Preliminary mechanistic studies revealed that the nucleophilic substitution proceeds on a eta(6)-complex of the Ru catalyst and the substrate, and the hemilabile ligand facilitates dissociation of products from the metal center.

引用

页码：3706 / 3711

页数：6

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