Have we achieved a unified model of photoreceptor cell fate specification in vertebrates?

被引：31

作者：

Adler, Ruben ^{[2
]}

Raymond, Pamela A. ^{[1
]}

机构：

[1] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[2] Johns Hopkins Univ, Wilmer Inst, Sch Med, Baltimore, MD 21287 USA

来源：

BRAIN RESEARCH | 2008年 / 1192卷

关键词：

retinal development; photoreceptor; opsin; cell fate specification;

D O I：

10.1016/j.brainres.2007.03.044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

How does a retinal progenitor choose to differentiate as a rod or a cone and, if it becomes a cone, which one of their different subtypes? The mechanisms of photoreceptor cell fate specification and differentiation have been extensively investigated in a variety of animal model systems, including human and non-human primates, rodents (mice and rats), chickens, frogs (Xenopus) and fish. It appears timely to discuss whether it is possible to synthesize the resulting information into a unified model applicable to all vertebrates. In this review we focus on several widely used experimental animal model systems to highlight differences in photoreceptor properties among species, the diversity of developmental strategies and solutions that vertebrates use to create retinas with photoreceptors that are adapted to the visual needs of their species, and the limitations of the methods currently available for the investigation of photoreceptor cell fate specification. Based on these considerations, we conclude that we are not yet ready to construct a unified model of photoreceptor cell fate specification in the developing vertebrate retina. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：134 / 150

页数：17

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