Surgical management of radiation-associated cutaneous breast angiosarcoma

被引:38
作者
Lindford, A. [1 ]
Bohling, T. [2 ,3 ]
Vaalavirta, L. [4 ]
Tenhunen, M. [4 ]
Jahkola, T. [1 ]
Tukiainen, E. [1 ]
机构
[1] Univ Helsinki, Cent Hosp, Toolo Hosp, Dept Plast Surg, Helsinki 00029, Finland
[2] Univ Helsinki, Peijas Hosp, Dept Pathol, Helsinki 00029, Finland
[3] HUSLAB, Helsinki 00029, Finland
[4] Univ Helsinki, Cent Hosp, Dept Radiat Oncol, Helsinki 00029, Finland
关键词
Radiotherapy; Breast cancer; Sarcoma; ATYPICAL VASCULAR-LESIONS; SOFT-TISSUE SARCOMA; CONSERVATIVE TREATMENT; CANCER; RISK; RADIOTHERAPY; CARCINOMA; THERAPY;
D O I
10.1016/j.bjps.2011.02.014
中图分类号
R61 [外科手术学];
学科分类号
摘要
The purpose of this study was to investigate the surgical management of radiation-associated cutaneous breast angiosarcoma with an emphasis on surgical margins and choice of reconstruction. Nine cases of angiosarcoma were identified in patients earlier treated with radiotherapy for breast cancer. Breast angiosarcoma was diagnosed a median of 5.25 years following radiotherapy. Median age at diagnosis was 60 years. Surgical treatment consisted of radical mastectomy (four cases), simple mastectomy (two cases) and wide local excision (three cases). Defect reconstruction involved three latissimus dorsi flap reconstructions and four skin grafts. Clear histological margins were achieved in all cases. Median follow-up was 81 months. Six patients were alive and disease-free at the end of the study period. Aggressive surgical resection with wide margins is essential to reduce local recurrence and improve survival. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1036 / 1042
页数:7
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