Suberosenone, a new cytotoxin from Subergorgia suberosa

被引：46

作者：

Bokesch, HR ^{[1
]}

McKee, TC ^{[1
]}

Cardellina, JH ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, DIV CANC TREATMENT DIAGNOSIS & CTR, FREDERICK, MD 21701 USA

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 19期

关键词：

D O I：

10.1016/0040-4039(96)00528-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The organic extract of the gorgonian Subergorgia suberosa was found to contain a novel cytotoxic sesquiterpene, suberosenone (1), as well as two known piscicidal sesquiterpenes, buddledins C and D. The structure of 1 was defined by spectral methods, including 1D and 2D NMR experiments. Suberosenone, the first quadrone-class sesquiterpene from the marine biosphere, exhibited relatively potent cytotoxicity to solid tumor lines in comparison to leukemia lines in the NCI's 60 cell line in vitro screen. Published by Elsevier Science Ltd.

引用

页码：3259 / 3262

页数：4

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