Oxidized to non-oxidized lipoprotein ratios are associated with arteriosclerosis and the metabolic syndrome in diabetic patients

被引：44

作者：

Girona, Josefa ^{[1
]}

Manzanares, Josep M. ^{[1
]}

Marimon, Francesc ^{[1
]}

Cabre, Anna ^{[1
]}

Heras, Mercedes ^{[1
]}

Guardiola, Montse ^{[1
]}

Ribalta, Josep ^{[1
]}

Masana, Lluis ^{[1
]}

机构：

[1] St Joan Univ Hosp Reus, Dept Internal Med, IRCIS,Res Unit Lipids & Atherosclerosis, Fac Med & Hlth Sci, Reus, Spain

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2008年 / 18卷 / 05期

关键词：

lipid peroxidation; atherosclerosis; metabolic syndrome; paraoxonase; 1; polymorphism; type; 2; diabetes;

D O I：

10.1016/j.numecd.2007.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aim: Type 2 diabetic patients have a greater prevalence of the metabolic syndrome, oxidative stress and accelerated atherosclerosis, compared to non-diabetics. We examined the association between biomarkers of lipid peroxidation and the presence of atherosclerosis and the metabolic syndrome in diabetic patients. Methods and results: We studied oxidized LDL (OxLDL), OxLDL/LDL, OxLDL/HDL, lipoperoxides, autoantibodies against OxLDL (OxLDL-Ab), diene formation of LDL (tag phase), vitamin E, vitamin E/cholesterol and PON1 polymorphisms (-108C > T, 55T > A, and 192A > G) in 166 non-smoking type 2 diabetic patients, 119 fulfilling the criteria for the metabolic syndrome, 73 with atherosclerosis and 93 without atherosclerosis. Patients with macrovascular disease had higher values of OxLDL/LDL (11%; P = 0.016), OxLDL/HDL (18%; P = 0.024) and OxLDL-Ab (12%; P = 0.046). OxLDL/LDL and OxLDL/HDL were correlated with the number of components of the metabolic syndrome (P < 0.001). PON1 polymorphisms were not associated to LDL oxidation markers, only PON1 (-108TT) was weakly associated with higher OxLDL-Ab concentrations (22%; P = 0.040) in patients with atherosclerosis.

引用

页码：380 / 387

页数：8

共 41 条

[1] Paraoxonase 55 and 192 polymorphism and its relationship to serum paraoxonase activity and serum lipids in Turkish patients with non-insulin dependent diabetes mellitus [J].