Novel N-sulfonamide trans-platinum complexes: synthesis, reactivity and in vitro evaluation

被引：24

作者：

Aleman, Jose ^{[1
]}

del Solar, Virginia ^{[2
]}

Alvarez-Valdes, Amparo ^{[2
]}

Rios-Luci, Carla ^{[3
]}

Padron, Jose M. ^{[3
]}

Navarro-Ranninger, Carmen ^{[2
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ C1, E-28049 Madrid, Spain

[2] Univ Autonoma Madrid, Dept Quim Inorgan C7, E-28049 Madrid, Spain

[3] Univ La Laguna, IUBO AG, San Cristobal la Laguna 38206, Spain

来源：

MEDCHEMCOMM | 2011年 / 2卷 / 08期

关键词：

METALLODRUG-PROTEIN INTERACTIONS; HEART CYTOCHROME-C; MASS-SPECTROMETRY; ANTICANCER; DRUGS; CISPLATIN; BIOMOLECULES; PHARMACOLOGY; MECHANISMS; INHIBITORS;

D O I：

10.1039/c1md00070e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, we described for the first time the synthesis of trans-N-sulfonamide platinum complexes. The antiproliferative activity (GI(50), mu M) of these new compounds in human solid tumors cells was compared to cisplatin.

引用

页码：789 / 793

页数：5

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