A preliminary study on L-lysine fermentation from lignocellulose feedstock and techno-economic evaluation

被引：23

作者：

Chen, Zeyu ^{[1
]}

Liu, Gang ^{[1
]}

Zhang, Jian ^{[1
]}

Bao, Jie ^{[1
]}

机构：

[1] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

来源：

BIORESOURCE TECHNOLOGY | 2019年 / 271卷

关键词：

L-Lysine; Corynebacterium glutamicum; Corn stover; Techno-economic analysis; Dry biorefinery processing; Minimum L-lysine selling price; PRETREATED CORN STOVER; CORYNEBACTERIUM-GLUTAMICUM; AMINO-ACIDS; SIMULTANEOUS SACCHARIFICATION; ETHANOL FERMENTATION; DETOXIFICATION; PERFORMANCE; INHIBITION; POTENTIALS;

D O I：

10.1016/j.biortech.2018.09.098

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

L-Lysine is a commodity amino acid produced from starch feedstock. Various alternative feedstocks had been used for L-lysine production, but the yield was very low. This study took the first preliminary investigation on L-lysine production from lignocellulose for the replacement of food-crop starch. Corn stover was dry acid pre-treated and biodetoxified, then used for enzymatic hydrolysis and L-lysine fermentation by an industrial Corynebacterium glutamicum strain. Various fermentation parameters, nutrient additions, and operation variables were applied and finally 33.8 g/L of L-lysine was obtained. This L-lysine titer is still below that of starch based fermentation, but already 3-5 folds greater than that of other alternative feedstocks based fermentation. A techno-economic analysis was conducted and the minimum selling price of L-lysine (hydrochloride form) was calculated to be $2.445 per kg. The cost reduction by the future improvement could fill the technical and economic gap between the cellulosic and starch based L-lysine production.

引用

页码：196 / 201

页数：6

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