Investigating the Role of Hypothalamic Tumor Involvement in Sleep and Cognitive Outcomes Among Children Treated for Craniopharyngioma

被引：27

作者：

Jacola, Lisa M. ^{[1
]}

Conklin, Heather M. ^{[1
]}

Scoggins, Matthew A. ^{[2
]}

Ashford, Jason M. ^{[1
]}

Merchant, Thomas E. ^{[3
]}

Mandrell, Belinda N. ^{[4
]}

Ogg, Robert J. ^{[2
]}

Curtis, Elizabeth ^{[5
]}

Wise, Merrill S. ^{[6
]}

Indelicato, Daniel J. ^{[7
]}

Crabtree, Valerie M. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Psychol, 262 Danny Thomas Pl,Mail Stop 740, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Diagnost Imaging, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Radiat Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[4] St Jude Childrens Res Hosp, Dept Nursing Res, 332 N Lauderdale St, Memphis, TN 38105 USA

[5] Indiana Univ Purdue Univ, Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[6] Methodist Healthcare Sleep Disorders Ctr, Memphis, TN USA

[7] Univ Florida, Coll Med, Dept Radiat Oncol, Gainesville, FL 32611 USA

来源：

JOURNAL OF PEDIATRIC PSYCHOLOGY | 2016年 / 41卷 / 06期

关键词：

cancer and oncology; neuropsychology; sleep; CHILDHOOD CRANIOPHARYNGIOMA; ADULT SURVIVORS; DAYTIME SLEEPINESS; DISTURBANCES; ATTENTION; OBESITY; FMRI; ADOLESCENTS; PERFORMANCE; THERAPY;

D O I：

10.1093/jpepsy/jsw026

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: Despite excellent survival prognosis, children treated for craniopharyngioma experience significant morbidity. We examined the role of hypothalamic involvement (HI) in excessive daytime sleepiness (EDS) and attention regulation in children enrolled on a Phase II trial of limited surgery and proton therapy. Methods: Participants completed a sleep evaluation (N = 62) and a continuous performance test (CPT) during functional magnetic resonance imaging (fMRI; n = 29) prior to proton therapy. Results: EDS was identified in 76% of the patients and was significantly related to increased HI extent (p = .04). There was no relationship between CPT performance during fMRI and HI or EDS. Visual examination of group composite fMRI images revealed greater spatial extent of activation in frontal cortical regions in patients with EDS, consistent with a compensatory activation hypothesis. Conclusion: Routine screening for sleep problems during therapy is indicated for children with craniopharyngioma, to optimize the timing of interventions and reduce long-term morbidity.

引用

页码：610 / 622

页数：13

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