LUNG CANCER Using ctDNA to track EGFR and KRAS mutations in advanced-stage disease

被引：29

作者：

Rosell, Rafael ^{[1
,2
]}

Karachaliou, Niki ^{[3
,4
]}

机构：

[1] Hosp Badalona Germans Trias & Pujol, Catalan Inst Oncol, Canc Biol & Precis Med Programme, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain

[2] Hlth Sci Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain

[3] Germans Trias & Pujol Hlth Sci Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain

[4] Hosp Univ Sagrat Cor, Calle Viladomat 288, Barcelona 08029, Spain

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2016年 / 13卷 / 07期

关键词：

NSCLC;

D O I：

10.1038/nrclinonc.2016.83

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Analysis of circulating tumour DNA (ctDNA) in blood samples provides a surrogate form of tumour biopsy (liquid biopsy) for determining EGFR and KRAS mutation status in patients with advanced-stage non-small-cell lung cancer. This approach obviates the need for a repeat biopsy, especially for the EGFR T790M mutation, which confers resistance to EGFR inhibition.

引用

页码：401 / 402

页数：2

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