Post-transcriptional gene regulation in chondrocytes

被引：2
作者：
Tew, Simon R. [1 ]
Clegg, Peter D. [1 ]
机构：
[1] Univ Liverpool, Dept Musculoskeletal Biol, Inst Ageing & Chron Dis, Neston CH64 7TE, Cheshire, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷
基金：
英国惠康基金;
关键词：
cartilage; chondrocyt; microRNA (miRNA); osteoarthritis; post transcriptional; regulation; TUMOR-NECROSIS-FACTOR; HUMAN ARTICULAR CHONDROCYTES; SOX9; MESSENGER-RNA; HISTONE DEACETYLASE-4; MICRORNA EXPRESSION; II COLLAGEN; TNF-ALPHA; CARTILAGE; INTERLEUKIN-1; MECHANISMS;
D O I：
10.1042/BST0381627
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The control of gene expression in articular chondrocytes is an essential factor in maintaining the homoeostasis of extracellular matrix synthesis and turnover necessary in healthy articular cartilage Although much is known of how steady state levels of gene expression and rates of transcription are altered there has been a poorer understanding of gene control at the post transcriptional level and its relevance to cartilage health and disease Now an emerging picture is developing of the importance of this tier of gene regulation driven by in vitro studies and mouse genetic models This level of cellular regulation represents an as yet unexplored area of potential intervention for the treatment of degenerative cartilage disorders such as osteoarthritis
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页码：1627 / 1631
页数：5
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