An Integrated 256-Channel Epiretinal Prosthesis

被引:193
作者
Chen, Kuanfu [1 ]
Yang, Zhi [1 ]
Hoang, Linh [1 ]
Weiland, James [2 ]
Humayun, Mark [2 ]
Liu, Wentai [1 ]
机构
[1] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
[2] Univ So Calif, Los Angeles, CA 90089 USA
关键词
Differential phase-shift keying (DPSK); functional electrical stimulation (FES); retinal prosthesis; telemetry; RETINAL PROSTHESIS; STIMULATION; RECOGNITION; PERFORMANCE; MICROCHIP; IMPLANTS; DESIGN; SYSTEM; CHIP;
D O I
10.1109/JSSC.2010.2055371
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
This paper reports an integrated 256-channel epiretinal prosthesis integrated circuit (IC). This epiretinal prosthesis system consists of a power telemetry subsystem to deliver 100 mW power, a data telemetry subsystem to transfer 2 Mbps data, digital controllers to decode stimulation patterns, and a 256-channel stimulator to generate user programmable bi-phasic current stimuli. In this study, dual-band telemetry is adopted to achieve both high power efficiency and high data rate. Frequencies of 2 and 22 MHz are chosen for power and data carrier frequencies, respectively. A mixed-mode and multiple-voltage design is applied to the stimulator for withstanding a high-compliance voltage of +/- 10 V at the output stage as well as for reducing the area of each pixel. To add flexibility to the stimulator, each pixel has a local digital controller, which enables the stimulator IC to generate 256 parallel stimulations with various pulse widths and amplitudes. The chip is fabricated in TSMC 0.18 mu m 32 V CMOS process with 256 area pads constructed above the stimulus current drivers.
引用
收藏
页码:1946 / 1956
页数:11
相关论文
共 35 条
[1]   The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa [J].
Chow, AY ;
Chow, VY ;
Packo, KH ;
Pollack, JS ;
Peyman, GA ;
Schuchard, R .
ARCHIVES OF OPHTHALMOLOGY, 2004, 122 (04) :460-469
[2]   A Highly Flexible System for Microstimulation of the Visual Cortex: Design and Implementation [J].
Coulombe, Jonathan ;
Sawan, Mohamad ;
Gervais, Jean-Francois .
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, 2007, 1 (04) :258-269
[3]   Real and virtual mobility performance in simulated prosthetic vision [J].
Dagnelie, Gislin ;
Keane, Pearse ;
Narla, Venkata ;
Yang, Liancheng ;
Weiland, James ;
Humayun, Mark .
JOURNAL OF NEURAL ENGINEERING, 2007, 4 (01) :S92-S101
[4]   A wide-band power-efficient inductive wireless link for implantable microelectronic devices using multiple-carriers [J].
Ghovanloo, Maysam ;
Atluri, Suresh .
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, 2007, 54 (10) :2211-2221
[5]  
Gray P. R., 2009, Analysis and Design of Analog Integrated Circuits, V5th edn
[6]   Visually guided performance of simple tasks using simulated prosthetic vision [J].
Hayes, JS ;
Yin, VT ;
Piyathaisere, D ;
Weiland, JD ;
Humayun, MS ;
Dagnelie, G .
ARTIFICIAL ORGANS, 2003, 27 (11) :1016-1028
[7]   Visual perception in a blind subject with a chronic microelectronic retinal prosthesis [J].
Humayun, MS ;
Weiland, JD ;
Fujii, GY ;
Greenberg, R ;
Williamson, R ;
Little, J ;
Mech, B ;
Cimmarusti, V ;
Van Boemel, G ;
Dagnelie, G ;
de Juan, E .
VISION RESEARCH, 2003, 43 (24) :2573-2581
[8]  
Jung LH, 2007, P ANN INT IEEE EMBS, P6597
[9]   Implant electronics for intraocular epiretinal neuro-stimulators [J].
Lehmann, Torsten ;
Lovell, Nigel H. ;
Suaning, Gregg J. ;
Preston, Philip ;
Wong, Yan T. ;
Dommel, Norbert ;
Jung, Louis Hyunsuk ;
Moghe, Yashodhan ;
Das, Kushal .
PROCEEDINGS OF 2008 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS, VOLS 1-10, 2008, :352-+
[10]   A neuro-stimulus chip with telemetry unit for retinal prosthetic device [J].
Liu, WT ;
Vichienchom, K ;
Clements, M ;
DeMarco, SC ;
Hughes, C ;
McGucken, E ;
Humayun, MS ;
de Juan, E ;
Weiland, JD ;
Greenberg, R .
IEEE JOURNAL OF SOLID-STATE CIRCUITS, 2000, 35 (10) :1487-1497