Adjuvant chemotherapy prior to postoperative concurrent chemoradiotherapy for locoregionally advanced head and neck cancer

被引：11

作者：

Choe, Kevin S. ^{[2
]}

Salama, Joseph K. ^{[1
]}

Stenson, Kerstin M. ^{[4
]}

Blair, Elizabeth A. ^{[4
]}

Witt, Mary Ellyn ^{[3
]}

Cohen, Ezra E. W. ^{[5
]}

Haraf, Daniel J. ^{[3
]}

Vokes, Everett E. ^{[3
,5
]}

机构：

[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA

[3] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

[4] Univ Chicago, Sect Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA

[5] Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA

来源：

RADIOTHERAPY AND ONCOLOGY | 2010年 / 97卷 / 02期

关键词：

Chemoradiotherapy; Induction chemotherapy; Head and neck cancer; Postoperative radiotherapy;

D O I：

10.1016/j.radonc.2010.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: Induction chemotherapy prior to definitive concurrent chemoradiotherapy (CCRT) is a promising treatment option for unresectable head and neck cancer (HNC). In the postoperative setting, the efficacy of such an approach with adjuvant chemotherapy (AdjCT) followed by postoperative CCRT is unclear. Materials and methods: Forty-one postoperative patients with stage III-IV (M0) HNC enrolled on 3 consecutive phase II clinical trials were retrospectively analyzed. Twenty-five of the patients were treated on a protocol which included AdjCT with carboplatin and paclitaxel prior to postoperative CCRT (AdjCT group). Sixteen were treated on protocols with similar postoperative CCRT but without AdjCT (control group). CCRT consisted of paclitaxel, 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy. Results: After a median follow-up of 72 months, there were no locoregional failures (LRF) or distant metastases (DM) in the AdjCT group. In the control group, there were 2 LRF and 2 DM. The 5-year risk of disease recurrence was 0% in the AdjCT group, compared to 28.9% in the control group (p = 0.0074). No patients had disease progression during AdjCT, and all proceeded to postoperative CCRT without delay. Conclusions: Adjuvant chemotherapy after surgery followed by CCRT may be a treatment strategy associated with favorable disease outcomes in locoregionally advanced HNC. These results pose a hypothesis which warrants further investigation. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 318-321

引用

页码：318 / 321

页数：4

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