Efficient and Chemoselective Amidation of β-Carboline Carboxylic Acids

被引：4

作者：

Lin, Miaoman ^{[1
]}

Liang, Weida ^{[1
]}

Ma, Jiale ^{[1
]}

Wu, Ye ^{[1
]}

Xiao, Xiao ^{[2
]}

Ying, Jianxi ^{[3
]}

Yan, Yinghua ^{[1
]}

Zhao, Lingling ^{[1
]}

Jin, Haixiao ^{[4
]}

Liang, Hongze ^{[1
]}

Cui, Wei ^{[2
]}

Yan, Xiaojun ^{[4
]}

机构：

[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Dept Chem, Ningbo 315211, Zhejiang, Peoples R China

[2] Ningbo Univ, Ningbo Key Lab Behav Neurosci, Zhejiang Prov Key Lab Pathophysiol, Sch Med, Ningbo 315211, Zhejiang, Peoples R China

[3] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China

[4] Ningbo Univ, Coll Food & Pharmaceut Sci, Ningbo 315211, Zhejiang, Peoples R China

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 44期

基金：

中国国家自然科学基金;

关键词：

Amidation; beta-Carboline; Fascaplysin; HBTU; Neuroprotection; MARINE NATURAL-PRODUCTS; AMIDE BOND FORMATION; ALKALOID FASCAPLYSIN; BIOLOGICAL-ACTIVITY; DESIGN; CHEMISTRY;

D O I：

10.1002/slct.201903444

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of beta-carboline amides has been synthesized in one-pot reaction via coupling between an acid and an amine in the presence of HBTU/Et3N. This mild amidation reaction undergoes efficiently and chemoselectively. Bioactivity studies indicate that the beta-carboline amide derivatives exhibit neuroprotective activity and might be developed to be lead compounds for anti-stroke agents.

引用

页码：12978 / 12982

页数：5

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