Cowden Syndrome: Recognizing and Managing a Not-So-Rare Hereditary Cancer Syndrome

被引：80

作者：

Mester, Jessica ^{[1
]}

Eng, Charis ^{[1
]}

机构：

[1] Cleveland Clin, Genom Med Inst, Cleveland, OH 44106 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2015年 / 111卷 / 01期

关键词：

(3-5); cowden syndrome; PTEN hamartoma tumor syndrome; hereditary cancer syndromes; AUTISM SPECTRUM DISORDERS; GERMLINE MUTATIONS; PTEN MUTATIONS; DISEASE; BREAST; GENE; INDIVIDUALS; RISKS; VARIANTS; BRCA1;

D O I：

10.1002/jso.23735

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cowden syndrome (CS) is an autosomal dominant hereditary cancer syndrome causing increased risk for breast, thyroid, renal, uterine, and other cancers as well as benign neoplasias and neurodevelopmental concerns. Timely diagnosis of affected patients is key, as early recognition allows for high-risk screening and other preventative measures prior to a patient enduring multiple cancer diagnoses. This review will highlight the cardinal features of CS and management recommendations for affected patients. J. Surg. Oncol. 2015 111:125-130. (c) 2014 Wiley Periodicals, Inc.

引用

页码：125 / 130

页数：6

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