共 50 条
- [31] Phase I evaluation of the PI3 kinase (PI3K) inhibitor taselisib (GDC-0032) in multiple locally advanced or metastatic PIK3CA mutant solid tumor types.JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)Jhaveri, Komal L.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USABedard, Philippe L.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USACejalvo, Juan Miguel论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAHart, Lowell L.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAJuric, Dejan论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAKelly, Karen论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USALockhart, A. Craig论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAMelnyk, Anton论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAMoore, Kathleen N.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USANemunaitis, John J.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAOliveira, Mafalda论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAPatel, Manish R.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USASachdev, Jasgit论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USASmith, David论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAVanderWalde, Ari论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAWare, Joseph A.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAJin, Huan论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAWilson, Timothy R.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USAWei, Michael C.论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USABaselga, Jose论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
- [32] Discovery of a novel and potent mutant-selective inhibitor of PI3KαCANCER RESEARCH, 2024, 84 (06)Gao, Mingming论文数: 0 引用数: 0 h-index: 0Qi, Chao论文数: 0 引用数: 0 h-index: 0Li, Zhentian论文数: 0 引用数: 0 h-index: 0Fan, Qipeng论文数: 0 引用数: 0 h-index: 0Wang, Liyang论文数: 0 引用数: 0 h-index: 0Zhou, Fei论文数: 0 引用数: 0 h-index: 0You, Lin论文数: 0 引用数: 0 h-index: 0Zheng, Hewen论文数: 0 引用数: 0 h-index: 0Li, Yu论文数: 0 引用数: 0 h-index: 0Wu, Liangxing论文数: 0 引用数: 0 h-index: 0Yao, Wenqing论文数: 0 引用数: 0 h-index: 0Liu, Phillip C.论文数: 0 引用数: 0 h-index: 0
- [33] Preclinical characterization of a novel PI3Kα H1047R mutant-selective inhibitorEUROPEAN JOURNAL OF CANCER, 2024, 211 : S59 - S59Smith, A. C.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAArwood-Levine, B.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USABorn, A.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAChatterjee, P.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAChicarelli, M. J.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAConner, M. L.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAFulton, J.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAHubert, H.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAKnox, H.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAMclean, B.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USANassar, K. W.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USANewhouse, B.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USANiman, S.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAStunkard, L.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USASutter, P.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USATurton, R.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAVan Gulick, R.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAVenteicher, B.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAVine, L.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USAZhou, Y.论文数: 0 引用数: 0 h-index: 0机构: Cogent Biosci, Res, Waltham, MA USA Cogent Biosci, Res, Waltham, MA USA
- [34] CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K InhibitorsCANCER CELL, 2014, 26 (01) : 136 - 149Vora, Sadhna R.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAJuric, Dejan论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAKim, Nayoon论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAMino-Kenudson, Mari论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAHuynh, Tiffany论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA论文数: 引用数: h-index:机构:Lockerman, Elizabeth L.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAPollack, Sarah F.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USALiu, Manway论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USALi, Xiaoyan论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USALehar, Joseph论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAWiesmann, Marion论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAWartmann, Markus论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAChen, Yan论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USACao, Z. Alexander论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAPinzon-Ortiz, Maria论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAKim, Sunkyu论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USASchlegel, Robert论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAHuang, Alan论文数: 0 引用数: 0 h-index: 0机构: Novartis Inst BioMed Res, Cambridge, MA 02139 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USAEngelman, Jeffrey A.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02120 USA
- [35] Treatment of PIK3CA and APC mutant colorectal cancers with dual PI3K/mTOR inhibition.JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)Tyler, Foley论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USAPayne, Susan论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USAYeuh, Alexander论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USAVan DeHey, Dana论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USAPasch, Cheri论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USAClipson, Linda论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USAMatkowskyj, Kristina论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USADeming, Dustin A.论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA
- [36] Dual PI3K/mTOR inhibition as a treatment strategy for PIK3CA and APC mutant colorectal cancersCANCER RESEARCH, 2016, 76Payne, Susan论文数: 0 引用数: 0 h-index: 0Foley, Tyler论文数: 0 引用数: 0 h-index: 0Pasch, Cheri论文数: 0 引用数: 0 h-index: 0Yueh, Alexander论文数: 0 引用数: 0 h-index: 0Korkos, Demetra论文数: 0 引用数: 0 h-index: 0Van De Hey, Dana论文数: 0 引用数: 0 h-index: 0Clipson, Linda论文数: 0 引用数: 0 h-index: 0Deming, Dustin论文数: 0 引用数: 0 h-index: 0
- [37] Discovery of GDC-0980, a selective PI3K/mTOR inhibitor in clinical trialsCANCER RESEARCH, 2011, 71Sutherlin, Daniel P.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USABelvin, Marcia论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USABao, Linda论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USABerry, Leanne论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USABerry, Megan论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USACastanedo, Georgette论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAEdgar, Kyle论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAFolkes, Adrian论文数: 0 引用数: 0 h-index: 0机构: Plramed, Slough, Berks, England Genentech Inc, San Francisco, CA 94080 USAFriedman, Lori论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAHeffron, Tim论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAPatel, Sonal论文数: 0 引用数: 0 h-index: 0机构: Plramed, Slough, Berks, England Genentech Inc, San Francisco, CA 94080 USAOlivero, Alan论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USALesnick, John论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USALewis, Cristina论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAMarsters, James论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USANonomiya, Jim论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAPang, Jodie论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAPrior, Wei Wei论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USASalphati, Laurent论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USASampath, Deepak论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USATsui, Vickie论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAWallin, Jeff论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAWei, BinQing论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAWeismann, Christian论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAZhu, Bing-Yan论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USA
- [38] PIK3CA regulates development of diabetes retinopathy through the PI3K/Akt/mTOR pathwayPLOS ONE, 2024, 19 (01):Guan, Ruijuan论文数: 0 引用数: 0 h-index: 0机构: Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R China Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R ChinaKang, Zefeng论文数: 0 引用数: 0 h-index: 0机构: China Acad Chinese Med Sci, Hosp Eye, Beijing, Peoples R China Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R ChinaLi, Ling论文数: 0 引用数: 0 h-index: 0机构: Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R China Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R ChinaYan, Xin论文数: 0 引用数: 0 h-index: 0机构: China Acad Chinese Med Sci, Hosp Eye, Beijing, Peoples R China Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R ChinaGao, Tianpeng论文数: 0 引用数: 0 h-index: 0机构: Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R China Qinghai Prov Peoples Hosp, Ophthalmol Dept, Xining, Qinghai, Peoples R China
- [39] Neuregulin-1 expression correlates with sensitivity to the PI3K inhibitor, GDC-0032, outside of PIK3CA mutations in head and neck cancerCANCER RESEARCH, 2014, 74 (19)Savage, Heidi M.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAO'Brien, Carol论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAYauch, Bob论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USASettleman, Jeff论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USALackner, Mark R.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAWilson, Timothy R.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USA
- [40] PIK3CA mutations and response to PI3K and MEK targeted therapies in NSCLCLUNG CANCER, 2013, 79 : S3 - S3Heavey, S.论文数: 0 引用数: 0 h-index: 0机构: St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, Ireland St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, IrelandDavies, M. A.论文数: 0 引用数: 0 h-index: 0机构: St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, Ireland St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, IrelandO'Byrne, K. J.论文数: 0 引用数: 0 h-index: 0机构: St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, Ireland St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, IrelandGately, K.论文数: 0 引用数: 0 h-index: 0机构: St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, Ireland St James Hosp, Trinity Ctr, Inst Mol Med, Dublin 8, Ireland