Intra-Articular Leukocyte-Rich Platelet-Rich Plasma versus Intra-Articular Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 14 Randomized Controlled Trials

被引:12
作者
Peng, Yu-Ning [1 ]
Chen, Jean-Lon [1 ]
Hsu, Chih-Chin [2 ]
Chen, Carl P. C. [1 ]
Suputtitada, Areerat [3 ]
机构
[1] Chang Gung Univ, Chang Gung Mem Hosp Linkou, Dept Phys Med & Rehabil, Coll Med, Taoyuan City 33343, Taiwan
[2] Chang Gung Univ, Chang Gung Mem Hosp Keelung, Dept Phys Med & Rehabil, Coll Med, Taoyuan City 33343, Taiwan
[3] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Dept Rehabil Med, Bangkok 10330, Thailand
关键词
knee; osteoarthritis; leukocyte-rich platelet-rich plasma; leukocyte-poor platelet-rich plasma; hyaluronic acid; DOUBLE-BLIND; CLINICAL-OUTCOMES; PRP INJECTIONS; VISCOSUPPLEMENTATION; EFFICACY; SINGLE;
D O I
10.3390/ph15080974
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
(1) Background: To evaluate the clinical effects of leukocyte-rich platelet-rich plasma (LR-PRP) and hyaluronic acid (HA) injections in treating patients suffering from knee osteoarthritis (OA); (2) Methods: Randomized controlled trials (RCTs) were searched from PubMed, Web of Science, and Cochrane Library. Keywords were: platelet-rich plasma, LR-PRP, leukocyte-rich, hyaluronic acid, and knee osteoarthritis. The included RCTs were published between the 1st of November 2011 and the 3rd of February 2021. Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores, visual analog scale (VAS) scores, International Knee Documentation Committee (IKDC) scores, and adverse events were used as outcomes for evaluation; (3) Results: A total of 14 RCTs were enrolled. At 6 months, revealed that the LR-PRP group was better than the HA group in WOMAC total, pain, and physical function scores. At 12 months, the LR-PRP group was better than the HA group in WOMAC stiffness and physical function scores. There was no significant difference in adverse events; (4) Conclusion: LR-PRP injection showed no significant pain relief effect as compared with HA injection. However, LR-PRP demonstrated better overall outcomes as compared to HA in knee OA patients at the follow-up periods of 3, 6, and 12 months. LR-PRP injection may be recommended as a feasible option in treating patients with knee OA.
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页数:16
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