Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

被引：297

作者：

Dolphin, Annette C. ^{[1
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2012年 / 13卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

GATED CA2+ CHANNELS; TISSUE-SPECIFIC EXPRESSION; SKELETAL-MUSCLE; RAT-BRAIN; TARGETED DISRUPTION; ANTIEPILEPTIC DRUGS; VOLTAGE-DEPENDENCE; GANGLION NEURONS; NEUROPATHIC PAIN; ALPHA(1) SUBUNIT;

D O I：

10.1038/nrn3311

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The voltage-gated calcium channel alpha(2)delta and beta subunits are traditionally considered to be auxiliary subunits that enhance channel trafficking, increase the expression of functional calcium channels at the plasma membrane and influence the channels' biophysical properties. Accumulating evidence indicates that these subunits may also have roles in the nervous system that are not directly linked to calcium channel function. For example, beta subunits may act as transcriptional regulators, and certain alpha(2)delta subunits may function in synaptogenesis. The aim of this Review is to examine both the classic and novel roles for these auxiliary subunits in voltage-gated calcium channel function and beyond.

引用

页码：542 / 555

页数：14

共 171 条

[1] Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79 [J].

Altier, C ;

Dubel, SJ ;

Barrère, C ;

Jarvis, SE ;

Stotz, SC ;

Spaetgens, RL ;

Scott, JD ;

Cornet, V ;

De Waard, M ;

Zamponi, GW ;

Nargeot, J ;

Bourinet, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (37) :33598-33603

[2] The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels [J].

Altier, Christophe ;

Garcia-Caballero, Agustin ;

Simms, Brett ;

You, Haitao ;

Chen, Lina ;

Walcher, Jan ;

Tedford, H. William ;

Hermosilla, Tamara ;

Zamponi, Gerald W. .

NATURE NEUROSCIENCE, 2011, 14 (02) :173-U252

[3] Cache -: a signaling domain common to animal Ca2+ channel subunits and a class of prokaryotic chemotaxis receptors [J].

Anantharaman, V ;

Aravind, L .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (11) :535-537

[4] Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha 2/delta subunit [J].

Angelotti, T ;

Hofmann, F .

FEBS LETTERS, 1996, 397 (2-3) :331-337

[5]

[Anonymous], COCHRANE DATABASE SY

[6] Auxiliary subunits: essential components of the voltage-gated calcium channel complex [J].

Arikkath, J ;

Campbell, KP .

CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (03) :298-307

[7] Critical role for the β regulatory subunits of Cav channels in T lymphocyte function [J].

Badou, Abdallah ;

Jha, Mithilesh Kumar ;

Matza, Didi ;

Mehal, Wajahat Z. ;

Freichel, Marc ;

Flockerzi, Veit ;

Flavell, Richard A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (42) :15529-15534

[8]

Ball SL, 2002, INVEST OPHTH VIS SCI, V43, P1595

[9] Genomic organization of the mouse and human α2δ2 voltage-dependent calcium channel subunit genes [J].

Barclay, J ;

Rees, M .

MAMMALIAN GENOME, 2000, 11 (12) :1142-1144

[10] Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells [J].

Barclay, J ;

Balaguero, N ;

Mione, M ;

Ackerman, SL ;

Letts, VA ;

Brodbeck, J ;

Canti, C ;

Meir, A ;

Page, KM ;

Kusumi, K ;

Perez-Reyes, E ;

Lander, ES ;

Frankel, WN ;

Gardiner, RM ;

Dolphin, AC ;

Rees, M .

JOURNAL OF NEUROSCIENCE, 2001, 21 (16) :6095-6104

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