IFN-γ 874A>T Genotype Is Associated With Higher CCR5 Expression in Peripheral Blood Mononuclear Cells From HIV plus Patients

被引：3
作者：
Liptrott, Neill J. [1 ,2 ]
Egan, Deirdre [1 ,2 ]
Back, David J. [1 ]
Owen, Andrew [1 ]
机构：
[1] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3GF, Merseyside, England
[2] Royal Liverpool & Broadgreen Univ Hosp Trust, NIHR Biomed Res Ctr, Liverpool, Merseyside, England
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2011年 / 58卷 / 05期
关键词：
cytokine polymorphism; HIV; interferon gamma; CCR5; CYTOKINE GENE POLYMORPHISMS; NUCLEAR RECEPTORS; INTERFERON-GAMMA; INFECTION; TRANSPLANTATION; MANIFESTATION; TUBERCULOSIS; LYMPHOCYTES; CHEMOKINE; RESPONSES;
D O I：
10.1097/QAI.0b013e318236441c
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We previously showed that certain cytokines impact on the expression of drug transporters and chemokine receptors in peripheral blood mononuclear cells. Known single-nucleotide polymorphism genes in the genes encoding interferon gamma (874A>T, rs62559044) and interleukin 2 (-330T>G, rs2069763) were genotyped in 66 HIV+ patients, and the impact of single-nucleotide polymorphisms on expression of ABCB1, ABCC1, ABCC2, CXCR4, and CCR5 in peripheral blood mononuclear cells from HIV+ patients was assessed. The IFN-gamma 874A>T allele and viral load were independently associated with CCR5 expression in patients. These associations have potential implications for HIV disease progression and treatment response that now warrant further study.
引用
收藏
页码：442 / 445
页数：4
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