The Importance of Apoptosis in Cancer Development and Treatment

被引：1

作者：

Gokbayrak Atay, Irem Nur ^{[1
]}

Gezer, Ayhan Hilal ^{[2
]}

Kasap, Elmas ^{[3
]}

机构：

[1] Dokuz Eylul Univ, Fac Hlth Sci Inst, Dept Neurosci, Izmir, Turkey

[2] Celal Bayar Univ, Fac Med, Dept Med Biol, Manisa, Turkey

[3] Celal Bayar Univ, Fac Med, Dept Internal Med & Gastroenterol, Manisa, Turkey

来源：

TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY | 2021年 / 36卷 / 03期

关键词：

Apoptosis; apoptosis pathways; cancer; cancer development; cancer treatment; DEATH RECEPTOR; C-FLIP; HEPATOCELLULAR-CARCINOMA; BH3-ONLY PROTEINS; BCL-2; FAMILY; IN-VIVO; EXPRESSION; BAX; OVEREXPRESSION; INHIBITOR;

D O I：

10.5505/tjo.2021.2574

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is one of the most important causes of death in our era. Multifactorial causes are involved in the formation of cancer. The reduction of apoptosis is one of these reasons. Failure to activate apoptosis pathways can lead to resistance to the current treatment approaches of cancers. A better understanding of the molecular events that regulate apoptosis in cancers and cancer therapy form the basis of a more rational approach to the development of molecular targeted therapies in the fight against cancer.

引用

页码：381 / 388

页数：8

共 50 条

[1] Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer
Bagnoli, Marina
Canevari, Silvana
Mezzanzanica, Delia
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (02) : 210 - 213
[2] The CD95 type I/type II model
Barnhart, BC
Alappat, EC
Peter, ME
[J]. SEMINARS IN IMMUNOLOGY, 2003, 15 (03) : 185 - 193
[3] Baykara O., 2016, Balikesir Saglik Bilimleri Dergisi, V5, P154, DOI [DOI 10.5505/BSBD.2016.93823, 10.5505/bsbd.2016.93823]
[4] A suppressive effect of the adenovirus 5 protein E1B 55K on apoptosis induced by IL-3 deprivation and γ-irradiation
Ben Jilani, KE
Gaillard, JP
Petit, F
Arnoult, D
Roumier, AS
Labalette, M
Ameisen, JC
Estaquier, J
[J]. BIOLOGY OF THE CELL, 2002, 94 (02) : 77 - 89
[5] Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs
Blagosklonny, MV
[J]. LEUKEMIA, 2002, 16 (04) : 455 - 462
[6] Targeted manipulation of apoptosis in cancer treatment
Call, Justin A.
Eckhardt, S. Gail
Camidge, D. Ross
[J]. LANCET ONCOLOGY, 2008, 9 (10) : 1002 - 1011
[7] DIFFERENTIAL EXPRESSION OF NUDT9 AT DIFFERENT PHASES OF THE MENSTRUAL CYCLE AND IN DIFFERENT COMPONENTS OF NORMAL AND NEOPLASTIC HUMAN ENDOMETRIUM
Chen, Ling-Yun
Chen, Tze-Ho
Wen, Pao-Ying
Chou, Chia-Hung
Ying, Tsung-Ho
Chang, Shun-Ping
Ma, Gwo-Chin
Chen, Ming
[J]. TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 2009, 48 (02): : 96 - 107
[8] Caspases: the executioners of apoptosis
Cohen, GM
[J]. BIOCHEMICAL JOURNAL, 1997, 326 : 1 - 16
[9] Cohen JJ., 1998, Postgraduate Syllabus, V1, P1
[10] Apoptosis
Cummings, MC
Winterford, CM
Walker, NI
[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1997, 21 (01) : 88 - 101

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