Insulin resistance in cognitive impairment - The InCHIANTI study

被引：82

作者：

Geroldi, C

Frisoni, GB

Paolisso, G

Bandinelli, S

Lamponi, M

Abbatecola, AM

Zanetti, O

Guralnik, JM

Ferrucci, L

机构：

[1] IRCCS San Govanni Dio FBF, Lab Epidemiol & Neuroimaging, I-25125 Brescia, Italy

[2] IRCCS San Govanni Dio FBF, Alzheimers Unit, I-25125 Brescia, Italy

[3] Univ Naples 2, Dept Geriatr Med & Metab Dis, Naples, Italy

[4] Italian Natl Res Ctr Aging Geriatr Dept, Lab Clin Epidemiol, Florence, Italy

[5] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD USA

[6] NIA, Clin Res Branch, Longitudinal Studies Sect, Baltimore, MD USA

来源：

ARCHIVES OF NEUROLOGY | 2005年 / 62卷 / 07期

关键词：

D O I：

10.1001/archneur.62.7.1067

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To test the association between cognitive impairment, with and without subcortical features, and insulin resistance in an elderly community-dwelling population. Design: Cross-sectional wave of an epidemiologic longitudinal study (InCHIANTI). Participants: A total of 523 people, aged 70 to 90 years without diabetes mellitus or hyperglycemia, from the InCHIANTI cohort were included in the study. A total of 119 individuals had cognitive impairment (MiniMental State Examination [MMSE] score < 25), 21 of whom had both cognitive impairment and subcortical features (CI/SF+ group). Control groups contained 23 individuals with a history of stroke and 381 individuals with no cognitive impairment (no CI group, MMSE score >= 25). Indicators of insulin resistance were the fasting plasma insulin level, insulin resistance index (Homeostasis Model Assessment of Insulin Resistance [HOMA-IR]), and insulin sensitivity index (Quantitative Insulin Sensitivity Check Index [QUICKI]).

引用

页码：1067 / 1072

页数：6

共 30 条

[1]

Baddeley A., 1986, WORKING MEMORY

[2] Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons [J].

Barbieri, M ;

Ferrucci, L ;

Ragno, E ;

Corsi, A ;

Bandinelli, S ;

Bonafè, M ;

Olivieri, F ;

Giovagnetti, S ;

Franceschi, C ;

Guralnik, JM ;

Paolisso, G .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 284 (03) :E481-E487

[3] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].

Cleeman, JI ;

Grundy, SM ;

Becker, D ;

Clark, LT ;

Cooper, RS ;

Denke, MA ;

Howard, WJ ;

Hunninghake, DB ;

Illingworth, DR ;

Luepker, RV ;

McBride, P ;

McKenney, JM ;

Pasternak, RC ;

Stone, NJ ;

Van Horn, L ;

Brewer, HB ;

Ernst, ND ;

Gordon, D ;

Levy, D ;

Rifkind, B ;

Rossouw, JE ;

Savage, P ;

Haffner, SM ;

Orloff, DG ;

Proschan, MA ;

Schwartz, JS ;

Sempos, CT ;

Shero, ST ;

Murray, EZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497

[4] Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose [J].

Craft, S ;

Asthana, S ;

Newcomer, JW ;

Wilkinson, CW ;

Matos, IT ;

Baker, LD ;

Cherrier, M ;

Lofgreen, C ;

Latendresse, S ;

Petrova, A ;

Plymate, S ;

Raskind, M ;

Grimwood, K ;

Veith, RC .

ARCHIVES OF GENERAL PSYCHIATRY, 1999, 56 (12) :1135-1140

[5] Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype [J].

Craft, S ;

Asthana, S ;

Cook, DG ;

Baker, LD ;

Cherrier, M ;

Purganan, K ;

Wait, C ;

Petrova, A ;

Latendresse, S ;

Watson, GS ;

Newcomer, JW ;

Schellenberg, GD ;

Krohn, AJ .

PSYCHONEUROENDOCRINOLOGY, 2003, 28 (06) :809-822

[6] Subsystems contributing to the decline in ability to walk: Bridging the gap between epidemiology and geriatric practice in the InCHIANTI study [J].

Ferrucci, L ;

Bandinelli, S ;

Benvenuti, E ;

Di Iorio, A ;

Macchi, C ;

Harris, TB ;

Guralnik, JM .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2000, 48 (12) :1618-1625

[7] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[8] Mild cognitive impairment with subcortical vascular features - Clinical characteristics and outcome [J].

Frisoni, GB ;

Galluzzi, S ;

Bresciani, L ;

Zanetti, O ;

Geroldi, C .

JOURNAL OF NEUROLOGY, 2002, 249 (10) :1423-1432

[9] Does insulin dysfunction play a role in Alzheimer's disease? [J].

Gasparini, L ;

Netzer, WJ ;

Greengard, P ;

Xu, HX .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (06) :288-293

[10] Prevalence and correlates of the insulin resistance syndrome among Native Americans - The Inter-Tribal Heart Project [J].

Greenlund, KJ ;

Valdez, R ;

Casper, ML ;

Rith-Najarian, S ;

Croft, JB .

DIABETES CARE, 1999, 22 (03) :441-447

← 1 2 3 →