Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

被引：18
|
作者：
Zhou, Xiaoying [1 ]
Guo, Lu [1 ]
Shi, Dandan [1 ]
Meng, Dong [1 ]
Sun, Xiao [1 ]
Shang, Mengmeng [1 ]
Liu, Xinxin [1 ,2 ,3 ]
Zhao, Yading [1 ]
Li, Jie [1 ]
机构：
[1] Shandong Univ, Qilu Hosp, Dept Ultrasound, West Wenhua Rd, Jinan, Shandong, Peoples R China
[2] Chinese Minist Hlth, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan, Peoples R China
[3] Shandong Univ, Qilu Hosp, Chinese Acad Med Sci, Jinan, Peoples R China
来源：
DRUG DELIVERY | 2020年 / 27卷 / 01期
基金：
中国国家自然科学基金;
关键词：
High biocompatibility; drug delivery system; chitosan nanodroplets; contrast-enhanced ultrasound imaging; spatiotemporally controlled delivery; DRUG-DELIVERY; NANOCARRIERS; NANOBUBBLES; PACLITAXEL; CODELIVERY; TRANSPORT; TOXICITY; CHITOSAN; NANO;
D O I：
10.1080/10717544.2020.1739170
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
As an injectable anticancer drug delivery system, the biological safety of nanocarriers is the most important prerequisite for their clinical application. The objective of our study was to synthesize special ultrasound-responsive highly biocompatible chitosan nanodroplets (BCNDs), observe their spatiotemporally control the delivery of doxorubicin (DOX) in vivo. The experimental results showed that the BCNDs were successfully prepared with high biosafety in vivo and great ultrasound imaging ability. DOX-BCNDs promoted the anticancer effects of DOX in vivo and inhibited the development of tumors. They also reduced the side effects to the heart and kidneys. In conclusion, BCNDs are a new type of smart nanocarrier with high biocompatibility and efficacy have great potential to be used in the clinic.
引用
收藏
页码：469 / 481
页数：13
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