Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

被引：27
|
作者：
Zhang, Yu-Hui [1 ,2 ]
Zhang, Ying-Ming [2 ]
Sheng, Xianliang [1 ]
Wang, Jie [1 ]
Liu, Yu [2 ,3 ]
机构：
[1] Inner Mongolia Agr Univ, Coll Sci, Hohhot 010018, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Dept Chem, Tianjin 300071, Peoples R China
[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 07期
关键词：
SILICA NANOPARTICLES; CANCER; DELIVERY; PRODRUG; THERANOSTICS; DIAGNOSTICS; MICELLES; VESICLES; REDOX;
D O I：
10.1039/c9cc08491f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and beta-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.
引用
收藏
页码：1042 / 1045
页数：4
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