Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

被引：27

作者：

Zhang, Yu-Hui ^{[1
,2
]}

Zhang, Ying-Ming ^{[2
]}

Sheng, Xianliang ^{[1
]}

Wang, Jie ^{[1
]}

Liu, Yu ^{[2
,3
]}

机构：

[1] Inner Mongolia Agr Univ, Coll Sci, Hohhot 010018, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Dept Chem, Tianjin 300071, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 07期

关键词：

SILICA NANOPARTICLES; CANCER; DELIVERY; PRODRUG; THERANOSTICS; DIAGNOSTICS; MICELLES; VESICLES; REDOX;

D O I：

10.1039/c9cc08491f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and beta-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.

引用

页码：1042 / 1045

页数：4

共 20 条

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