SRPK2 promotes the growth and migration of the colon cancer cells

被引：29
作者：
Wang, Jian [1 ,2 ]
Wu, Hai-Feng [3 ]
Shen, Wei [4 ]
Xu, Dong-Yan [2 ,5 ]
Ruan, Ting-Yan [6 ]
Tao, Guo-Qing [4 ]
Lu, Pei-hua [6 ]
机构：
[1] Xuzhou Med Coll, Huaian Hosp, Dept Gastrointestinal Surg, 62 Huai Hai South Rd, Huaan 223200, Jiangsu, Peoples R China
[2] Huaian Second Peoples Hosp, 62 Huai Hai South Rd, Huaan 223200, Jiangsu, Peoples R China
[3] Jiangsu Univ, Affiliated Yixing Peoples Hosp, Dept Crit Care Med, 75 Tongzhenguan Rd, Yixing 214200, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Gen Surg, Wuxi 214023, Jiangsu, Peoples R China
[5] Xuzhou Med Coll, Huaian Hosp, Dept Gastroenterol, 62 Huai Hai South Rd, Huaian 223200, Jiangsu, Peoples R China
[6] Nanjing Med Univ, Dept Med Oncol, Wuxi Peoples Hosp, Wuxi 214023, Jiangsu, Peoples R China
来源：
GENE | 2016年 / 586卷 / 01期
关键词：
Colon cancer; SRPK2; ERK; Cell growth and migration; PROTEIN-SPECIFIC KINASE; UP-REGULATION; PATHWAY; RESISTANCE; PROLIFERATION; LOCALIZATION; SURVIVAL; MUTATION; LIVER; CYCLE;
D O I：
10.1016/j.gene.2016.03.051
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Colon cancer is one of the major causes of cancer-related death in the world. Understanding the molecular mechanism underlying this malignancy will facilitate the diagnosis and treatment. Serine-arginine protein kinase 2 (SRPK2) has been reported to be upregulated in several cancer types. However, its expression and functions in colon cancer remains unknown. In this study, it was found that the expression of SRPK2 was up-regulated in the clinical colon cancer samples. Overexpression of SRPK2 promoted the growth and migration of colon cancer cells, while knocking down the expression of SRPK2 inhibited the growth, migration and tumorigenecity of colon cancer cells. Molecular mechanism studies revealed that SRPK2 activated ERK signaling in colon cancer cells. Taken together, our study demonstrated the tumor promoting roles of SRPK2 in colon cancer cells and SRPK2 might be a promising therapeutic target for colon cancer. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：41 / 47
页数：7
相关论文
共 50 条
  • [41] LncRNA IGFL2-AS1 Promotes the Proliferation, Migration, and Invasion of Colon Cancer Cells and is Associated with Patient Prognosis
    Cen, Xiaoning
    Huang, Yunmei
    Lu, Zhuangnian
    Shao, Wenjun
    Zhuo, Chenyi
    Bao, Chongchan
    Feng, Shi
    Wei, Cheng
    Tang, Xiqiang
    Cen, Lijun
    Guo, Wenwen
    Tian, Xinru
    Tang, Qianli
    Huang, Xusen
    CANCER MANAGEMENT AND RESEARCH, 2021, 13 : 5957 - 5968
  • [42] Thunder god vine extract exerts antiproliferative effects on growth of human colon cancer cells and inhibits colon cancer growth in xenograft mice models
    Zhu, H.
    Lv, G.
    Qu, Q.
    Xu, J.
    Zhang, L.
    Zhu, Y.
    SOUTH AFRICAN JOURNAL OF BOTANY, 2018, 115 : 18 - 23
  • [43] Primary structural features of SR-like protein acinusS govern the phosphorylation mechanism by SRPK2
    Liang, Ning
    Zeng, Chuyue
    Tao, Kin Pong
    Sou, Weng Hong
    Hsia, Ho Pan
    Qu, Dan
    Lau, Sze Nga
    Ngo, Jacky Chi Ki
    BIOCHEMICAL JOURNAL, 2014, 459 : 181 - 191
  • [44] The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells
    Tazehkand, Abbas Pirpour
    Akbarzadeh, Maryam
    Velaie, Kobra
    Sadeghi, Mohammad Reza
    Samadi, Nasser
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 103 : 755 - 766
  • [45] SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells
    Liu, Yang
    Liu, Junying
    Kong, Xin
    Li, Han
    Shao, Jianying
    Jiang, Ziting
    EJSO, 2020, 46 (10): : 1912 - 1917
  • [46] miR-31 promotes proliferation of colon cancer cells by targeting E2F2
    Li, Tong
    Luo, Wenjing
    Liu, Kunmei
    Lv, Xiaobo
    Xi, Tao
    BIOTECHNOLOGY LETTERS, 2015, 37 (03) : 523 - 532
  • [47] NDC80 promotes proliferation and metastasis of colon cancer cells
    Xing, X. K.
    Wu, H. Y.
    Chen, H. L.
    Feng, H. G.
    GENETICS AND MOLECULAR RESEARCH, 2016, 15 (02)
  • [48] Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells
    Lu, Haoming
    Feng, Ying
    Hu, Yilin
    Guo, Yibing
    Liu, Yifei
    Mao, Qinsheng
    Xue, Wanjiang
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (01) : 98 - 113
  • [49] Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK1/2/CREB signaling pathways
    Liu, Fu-Hong
    Lin, Xing-Cheng
    Liu, Yu-Wei
    Zhang, Tian-Tian
    Zhang, Yang-Bo
    Xie, Zhuo-Long
    Zhan, Yuan
    Hu, Ping
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2025, 27 (01) : 75 - 87
  • [50] A reciprocal feedback between colon cancer cells and Schwann cells promotes the proliferation and metastasis of colon cancer
    Shengbo Han
    Decai Wang
    Yan Huang
    Zhu Zeng
    Peng Xu
    Hewei Xiong
    Zunxiang Ke
    Ya Zhang
    Yuhang Hu
    Fan Wang
    Jie Wang
    Yong Zhao
    Wenfeng Zhuo
    Gang Zhao
    Journal of Experimental & Clinical Cancer Research, 41
12345