SRPK2 promotes the growth and migration of the colon cancer cells

被引：29
作者：
Wang, Jian [1 ,2 ]
Wu, Hai-Feng [3 ]
Shen, Wei [4 ]
Xu, Dong-Yan [2 ,5 ]
Ruan, Ting-Yan [6 ]
Tao, Guo-Qing [4 ]
Lu, Pei-hua [6 ]
机构：
[1] Xuzhou Med Coll, Huaian Hosp, Dept Gastrointestinal Surg, 62 Huai Hai South Rd, Huaan 223200, Jiangsu, Peoples R China
[2] Huaian Second Peoples Hosp, 62 Huai Hai South Rd, Huaan 223200, Jiangsu, Peoples R China
[3] Jiangsu Univ, Affiliated Yixing Peoples Hosp, Dept Crit Care Med, 75 Tongzhenguan Rd, Yixing 214200, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Gen Surg, Wuxi 214023, Jiangsu, Peoples R China
[5] Xuzhou Med Coll, Huaian Hosp, Dept Gastroenterol, 62 Huai Hai South Rd, Huaian 223200, Jiangsu, Peoples R China
[6] Nanjing Med Univ, Dept Med Oncol, Wuxi Peoples Hosp, Wuxi 214023, Jiangsu, Peoples R China
来源：
GENE | 2016年 / 586卷 / 01期
关键词：
Colon cancer; SRPK2; ERK; Cell growth and migration; PROTEIN-SPECIFIC KINASE; UP-REGULATION; PATHWAY; RESISTANCE; PROLIFERATION; LOCALIZATION; SURVIVAL; MUTATION; LIVER; CYCLE;
D O I：
10.1016/j.gene.2016.03.051
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Colon cancer is one of the major causes of cancer-related death in the world. Understanding the molecular mechanism underlying this malignancy will facilitate the diagnosis and treatment. Serine-arginine protein kinase 2 (SRPK2) has been reported to be upregulated in several cancer types. However, its expression and functions in colon cancer remains unknown. In this study, it was found that the expression of SRPK2 was up-regulated in the clinical colon cancer samples. Overexpression of SRPK2 promoted the growth and migration of colon cancer cells, while knocking down the expression of SRPK2 inhibited the growth, migration and tumorigenecity of colon cancer cells. Molecular mechanism studies revealed that SRPK2 activated ERK signaling in colon cancer cells. Taken together, our study demonstrated the tumor promoting roles of SRPK2 in colon cancer cells and SRPK2 might be a promising therapeutic target for colon cancer. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：41 / 47
页数：7
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