Synthesis and antifungal activity of camphoric acid-based acylhydrazone compounds

被引：13

作者：

Ma, Xian-Li ^{[1
,2
]}

Li, Fang-Yao ^{[1
,2
]}

Duan, Wen-Gui ^{[1
]}

Liao, Jing-Ni ^{[1
]}

Lin, Zhi-duo ^{[1
]}

Lin, Gui-Shan ^{[1
]}

Cen, Bo ^{[1
]}

Lei, Fu-Hou ^{[3
]}

机构：

[1] Guangxi Univ, Sch Chem & Chem Engn, Nanning 530004, Peoples R China

[2] Guilin Med Univ, Coll Pharm, Guilin, Peoples R China

[3] Guangxi Key Lab Chem & Engn Forest Prod, Nanning, Peoples R China

来源：

HOLZFORSCHUNG | 2014年 / 68卷 / 08期

基金：

中国国家自然科学基金;

关键词：

acylhydrazone; antifungal activity; camphoric acid; synthesis; ANTIBACTERIAL ACTIVITIES;

D O I：

10.1515/hf-2014-0002

中图分类号：

S7 [林业];

学科分类号：

0829 ; 0907 ;

摘要：

In the search of novel potent bioactive compounds, 18 novel camphoric acid-based acylhydrazone compounds 4a-4r were designed and synthesized by the condensation reaction of N-amino camphorimide (3) with substituted benzaldehyde based on camphoric acid as the starting material. The target compounds were characterized by means of Fourier transform infrared (FTIR), H-1 nuclear magnetic resonance (NMR), C-13 NMR, electrospray ionization-mass spectrometry (ESI-MS), and elemental analysis. The preliminary bioassay showed that the following camphoric acid-based compounds exhibited excellent antifungal activity with an inhibition ratio of 95% against Physalospora piricola at the concentration of 50 mu g ml(-1): o-bromophenyl acylhydrazone (4f), p-bromophenyl acylhydrazone (4g), p-methoxyphenyl acylhydrazone (4m), and p-hydroxyphenyl acylhydrazone (4p).

引用

页码：889 / 895

页数：7

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