Epidemiology, Treatments, and Vaccine Development for Antimicrobial-Resistant Neisseria gonorrhoeae: Current Strategies and Future Directions

被引：40

作者：

Lin, Eric Y. ^{[1
]}

Adamson, Paul C. ^{[2
]}

Klausner, Jeffrey D. ^{[3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Div Infect Dis, David Geffen Sch Med, 10833 Le Conte Ave CHS 52-215, Los Angeles, CA 90095 USA

[3] USC, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA

来源：

DRUGS | 2021年 / 81卷 / 10期

基金：

美国国家卫生研究院;

关键词：

IN-VITRO ACTIVITY; MENINGOCOCCAL B VACCINE; TIME PCR ASSAY; DECREASED SUSCEPTIBILITY; ANTIBACTERIAL ACTIVITY; EUROPEAN COUNTRIES; CEFTRIAXONE; ETX0914; CIPROFLOXACIN; INFECTION;

D O I：

10.1007/s40265-021-01530-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neisseria gonorrhoeae is the second most common bacterial sexually transmitted infection in the world after Chlamydia trachomatis. The pathogen has developed resistance to every antibiotic currently approved for treatment, and multidrug-resistant strains have been identified globally. The current treatment recommended by the World Health Organization is ceftriaxone and azithromycin dual therapy. However, resistance to azithromycin and ceftriaxone are increasing and treatment failures have been reported. As a result, there is a critical need to develop novel strategies for mitigating the spread of antimicrobial-resistant N. gonorrhoeae through improved diagnosis and treatment of resistant infections. Strategies that are currently being pursued include developing molecular assays to predict resistance, utilizing higher doses of ceftriaxone, repurposing older antibiotics, and developing newer agents. In addition, efforts to discover a vaccine for N. gonorrhoeae have been reignited in recent years with the cross-protectivity provided by the N. meningitidis vaccine, with several new strategies and targets. Despite the significant progress that has been made, there is still much work ahead to combat antimicrobial-resistant N. gonorrhoeae globally.

引用

页码：1153 / 1169

页数：17

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